TWSG1

TWSG1
Identifiers
Aliases	TWSG1, TSG, twisted gastrulation BMP signaling modulator 1
External IDs	OMIM: 605049; MGI: 2137520; HomoloGene: 10774; GeneCards: TWSG1; OMA:TWSG1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	9,402,420 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	66,258,221 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; cartilage tissue; ; germinal epithelium; ; caput epididymis; ; corpus epididymis; ; tibia; ; tail of epididymis; ; visceral pleura; ; parietal pleura; ; Descending thoracic aorta;
	Top expressed in
	cumulus cell; ; tail of embryo; ; ascending aorta; ; aortic valve; ; medullary collecting duct; ; genital tubercle; ; corneal stroma; ; efferent ductule; ; right ventricle; ; molar;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; transforming growth factor beta binding;
Cellular component	extracellular region; extracellular space;
Biological process	negative regulation of BMP signaling pathway; multicellular organism development; mesoderm formation; cell differentiation; forebrain development; camera-type eye development; salivary gland morphogenesis; BMP signaling pathway; ossification; negative regulation of osteoblast differentiation; tissue development; positive regulation of BMP signaling pathway; negative regulation of cytokine production; transforming growth factor beta receptor signaling pathway; positive regulation of pathway-restricted SMAD protein phosphorylation; negative regulation of CD4-positive, alpha-beta T cell activation; negative regulation of CD4-positive, alpha-beta T cell proliferation; hemopoiesis;
	Sources:Amigo / QuickGO
Orthologs
	57045
	65960
	ENSG00000128791
	ENSMUSG00000024098
	Q9GZX9
	Q9EP52
	NM_020648
	NM_023053
	NP_065699
	NP_075540
	Wikidata
View/Edit Human	View/Edit Mouse

Twisted gastrulation protein homolog 1 is a protein that in humans is encoded by the TWSG1 gene.^[5]^[6] The protein is a binding protein for bone morphogenetic proteins, similar to Chordin.^[7] The Twisted gastrulation gene is expressed in the extraembryonic tissues during organogenesis, and in certain adult tissues such as the lymph nodes, kidneys, liver, and lungs.^[8]