TXNDC12

Thioredoxin domain-containing protein 12 is a protein that in humans is encoded by the TXNDC12 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesTXNDC12, AG1, AGR1, ERP16, ERP18, ERP19, PDIA16, TLP19, hAG-1, hTLP19, thioredoxin domain containing 12

External IDsOMIM: 609448; MGI: 1913323; HomoloGene: 41074; GeneCards: TXNDC12; OMA:TXNDC12 - orthologs

Chr.Chromosome 1 (human)^[1]

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TXNDC12
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1SEN, 2K8V
Identifiers
Aliases	TXNDC12, AG1, AGR1, ERP16, ERP18, ERP19, PDIA16, TLP19, hAG-1, hTLP19, thioredoxin domain containing 12
External IDs	OMIM: 609448; MGI: 1913323; HomoloGene: 41074; GeneCards: TXNDC12; OMA:TXNDC12 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p32.3 Start 52,020,131 bp[1] End 52,055,191 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C7 Start 108,691,798 bp[2] End 108,719,324 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte rectum gonad stromal cell of endometrium body of pancreas islet of Langerhans ventricular zone placenta gallbladder olfactory zone of nasal mucosa Top expressed in medial ganglionic eminence spermatocyte endocardial cushion dermis calvaria epithelium of lens atrium efferent ductule atrioventricular valve yolk sac More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity protein-disulfide reductase (glutathione) activity protein binding Cellular component endoplasmic reticulum lumen endoplasmic reticulum Biological process negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway cell redox homeostasis cell differentiation negative regulation of cell death Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51060 66073 Ensembl ENSG00000117862 ENSMUSG00000028567 UniProt O95881 Q9CQU0 RefSeq (mRNA) NM_015913 NM_025334 RefSeq (protein) NP_056997 NP_079610 Location (UCSC) Chr 1: 52.02 – 52.06 Mb Chr 4: 108.69 – 108.72 Mb PubMed search [3] [4]
Wikidata
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TXNDC12 belongs to the thioredoxin superfamily (see TXN; MIM 187700). Members of this superfamily possess a thioredoxin fold with a consensus active-site sequence (CxxC) and have roles in redox regulation, defense against oxidative stress, refolding of disulfide-containing proteins, and regulation of transcription factors^[8] (Liu et al., 2003).[supplied by OMIM]^[7]