Tampramine

Tampramine (AHR-9,377) is a tricyclic antidepressant (TCA) which was developed in the 1980s but was never marketed.^[1][2] Despite being a TCA, it acts as a selective norepinephrine reuptake inhibitor and has negligible affinity for adrenergic, histaminergic, and muscarinic receptors.^[1] It was found to be effective in the forced swim test (FST) model of depression in animal studies but is not known to have ever been trialed in humans.^[2]

Routes of
administrationOral

Legal status

• In general: uncontrolled

CAS Number

• 83166-17-0
  83166-18-1 (fumarate)

PubChem CID

• 54961

Quick facts Clinical data, Routes ofadministration ...

Tampramine

Clinical data
Routes of administration	Oral
Legal status
Legal status	In general: uncontrolled
Identifiers
IUPAC name N,N-Dimethyl-3-(6-phenylpyrido[2,3-b][1,4]benzodiazepin-11-yl)propan-1-amine
CAS Number	83166-17-0 83166-18-1 (fumarate)
PubChem CID	54961
ChemSpider	49631
UNII	47GSE5RM8N
CompTox Dashboard (EPA)	DTXSID00232203
Chemical and physical data
Formula	C23H24N4
Molar mass	356.473 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN(C)CCCN1c2ccccc2C(=Nc3c1nccc3)c4ccccc4

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