Tenilapine

Atypical antipsychotic From Wikipedia, the free encyclopedia

Tenilapine is an atypical antipsychotic which has never been marketed in the US.

CAS Number
Quick facts Identifiers, CAS Number ...
Tenilapine
INN: tenilapine
Identifiers
  • (2E)-[5-(4-Methyl-1-piperazinyl)-9H-bisthieno[3,4-b:3',4'-e]azepin-9-ylidene]acetonitrile
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC17H16N4S2
Molar mass340.46 g·mol−1
3D model (JSmol)
  • CN1CCN(CC1)C2=NC3=CSC=C3/C(=C/C#N)/C4=CSC=C42
  • InChI=1S/C17H16N4S2/c1-20-4-6-21(7-5-20)17-15-10-22-8-13(15)12(2-3-18)14-9-23-11-16(14)19-17/h2,8-11H,4-7H2,1H3/b12-2+
  • Key:RVQVUMIXBGFJLZ-SWGQDTFXSA-N
Close

Pharmacodynamics

Tenilapine has a relatively high affinity for the 5-HT2A receptor, and relatively low (micromolar) affinities for dopamine receptors.

More information Receptor, Ki (nM) ...
Binding affinities
ReceptorKi (nM)
D21584[1]
D4721±300[1]
5-HT2A40[1]
Close

The ratio of D2 to D4 bonding is similar to that of clozapine.[1] Like many other atypical antipsychotics, it is a potent 5-HT2C antagonist.[2]

References

Related Articles

Wikiwand AI