Thio-THIP
Pharmaceutical compound
From Wikipedia, the free encyclopedia
Thio-THIP, also known as 4,5,6,7-tetrahydroisothiazolo[5,4-c]pyridin-3-ol, is a low-potency GABAA receptor very weak partial agonist or antagonist related to gaboxadol (THIP).[1][2][3] It is also a weak GABAA-ρ receptor antagonist[4][5] and a weak GABA reuptake inhibitor.[2] The drug has three orders of magnitude lower potency as a GABAA receptor modulator than gaboxadol.[6][7] This is unlike the case of muscimol and thiomuscimol, which are almost equipotent.[8] Like gaboxadol, thio-THIP is a zwitterion.[1][8] It may cross the blood–brain barrier similarly to gaboxadol.[8] Thio-THIP was developed and described by Povl Krogsgaard-Larsen and colleagues by 1981.[6][9][7]
Other names4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol; Thiogaboxadol
Drug classGABAA receptor weak partial agonist or antagonist; GABAA-ρ receptor antagonist; GABA reuptake inhibitor
ATC code
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| Other names | 4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol; Thiogaboxadol |
| Drug class | GABAA receptor weak partial agonist or antagonist; GABAA-ρ receptor antagonist; GABA reuptake inhibitor |
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| Formula | C6H8N2OS |
| Molar mass | 156.20 g·mol−1 |
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