Tilorone

Tilorone (trade names Amixin, Lavomax and others) is the first recognized synthetic, small molecular weight compound that is an orally active interferon inducer.^[2] It is used as an antiviral drug in some countries which do not require double-blind placebo-controlled studies, including Russia. It is effective against Ebola virus in mice.^[3] It shows activity against Eastern equine encephalitis and related viruses.^[4]

AHFS/Drugs.comInternational Drug Names

Routes of
administrationBy mouth (tablets)

ATC code

• J05AX19 (WHO)

Bioavailability60%

Quick facts Clinical data, AHFS/Drugs.com ...

Tilorone

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	By mouth (tablets)
ATC code	J05AX19 (WHO)
Pharmacokinetic data
Bioavailability	60%
Protein binding	~80%
Metabolism	Nil
Elimination half-life	48 hours
Excretion	Feces (70%), urine (9%)[1]
Identifiers
IUPAC name 2,7-Bis(2-diethylaminoethoxy)fluoren-9-one
CAS Number	27591-97-5 Y
PubChem CID	5475
ChemSpider	5276 N
UNII	O6W7VEW6KS
KEGG	D06149 N
ChEBI	CHEBI:147347
ChEMBL	ChEMBL47298 N
CompTox Dashboard (EPA)	DTXSID1045958
Chemical and physical data
Formula	C25H34N2O3
Molar mass	410.558 g·mol−1
3D model (JSmol)	Interactive image
SMILES CCN(CC)CCOc1ccc-2c(c1)C(=O)c3c2ccc(c3)OCCN(CC)CC
InChI InChI=1S/C25H34N2O3/c1-5-26(6-2)13-15-29-19-9-11-21-22-12-10-20(30-16-14-27(7-3)8-4)18-24(22)25(28)23(21)17-19/h9-12,17-18H,5-8,13-16H2,1-4H3 N Key:MPMFCABZENCRHV-UHFFFAOYSA-N N
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