U-41792

U-41792
Identifiers
	IUPAC name 1-[4-(1-adamantyloxy)phenyl]piperidine;
CAS Number	56714-70-6;
PubChem CID	64390;
ChemSpider	57960;
ChEMBL	ChEMBL3228507;
CompTox Dashboard (EPA)	DTXSID70972164 ;
Chemical and physical data
Formula	C21H29NO
Molar mass	311.469 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CCN(CC1)C2=CC=C(C=C2)OC34CC5CC(C3)CC(C5)C4;
	InChI InChI=1S/C21H29NO/c1-2-8-22(9-3-1)19-4-6-20(7-5-19)23-21-13-16-10-17(14-21)12-18(11-16)15-21/h4-7,16-18H,1-3,8-15H2; Key:NMFLMLJPBJHWSE-UHFFFAOYSA-N;

U-41792 is a small molecule developed by the Upjohn Company as a hypobetalipoproteinemic agent, meaning it lowers levels of beta-lipoproteins, including low-density lipoprotein (LDL) such as apolipoprotein B, in the blood.^[1] Elevated LDL levels can lead to early-onset atherosclerosis and increase the risk of heart problems.^[2]

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U-41792 demonstrated its ability to reduce lipid levels in hyperlipemic rats.^[3]^[4]^[5]

Synthesis

Identifiers

IUPAC name 1-[4-(1-adamantyloxy)phenyl]piperidine
CAS Number	56714-70-6
PubChem CID	64390
ChemSpider	57960
ChEMBL	ChEMBL3228507
CompTox Dashboard (EPA)	DTXSID70972164
Chemical and physical data
Formula	C₂₁H₂₉NO
Molar mass	311.469 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES C1CCN(CC1)C2=CC=C(C=C2)OC34CC5CC(C3)CC(C5)C4
InChI InChI=1S/C21H29NO/c1-2-8-22(9-3-1)19-4-6-20(7-5-19)23-21-13-16-10-17(14-21)12-18(11-16)15-21/h4-7,16-18H,1-3,8-15H2 Key:NMFLMLJPBJHWSE-UHFFFAOYSA-N