UBE2E1

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Ubiquitin-conjugating enzyme E2 E1 is a protein that in humans is encoded by the UBE2E1 gene.[5][6]

PDBOrtholog search: PDBe RCSB
AliasesUBE2E1, UBCH6, ubiquitin conjugating enzyme E2 E1
Quick facts Available structures, PDB ...
UBE2E1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUBE2E1, UBCH6, ubiquitin conjugating enzyme E2 E1
External IDsOMIM: 602916; MGI: 107411; HomoloGene: 84372; GeneCards: UBE2E1; OMA:UBE2E1 - orthologs
EC number2.3.2.24
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001202476
NM_003341
NM_182666

NM_009455

RefSeq (protein)

NP_001189405
NP_003332
NP_872607
NP_003332.1

NP_033481

Location (UCSC)Chr 3: 23.81 – 23.89 MbChr 14: 4.14 – 4.19 Mb
PubMed search[3][4]
Wikidata
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Function

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[6]

Interactions

UBE2E1 has been shown to interact with Ataxin 1[7] and NEDD4.[8][9]

References

Further reading

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