UBE2G1

Ubiquitin-conjugating enzyme E2 G1 is a protein that in humans is encoded by the UBE2G1 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesUBE2G1, E217K, UBC7, UBE2G, ubiquitin conjugating enzyme E2 G1

External IDsOMIM: 601569; MGI: 1914378; HomoloGene: 2508; GeneCards: UBE2G1; OMA:UBE2G1 - orthologs

Chr.Chromosome 17 (human)^[1]

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UBE2G1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AWF
Identifiers
Aliases	UBE2G1, E217K, UBC7, UBE2G, ubiquitin conjugating enzyme E2 G1
External IDs	OMIM: 601569; MGI: 1914378; HomoloGene: 2508; GeneCards: UBE2G1; OMA:UBE2G1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.2 Start 4,269,259 bp[1] End 4,366,675 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B4 Start 72,498,109 bp[2] End 72,577,307 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm secondary oocyte biceps brachii vastus lateralis muscle Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii glutes deltoid muscle muscle of thigh tibialis anterior muscle Top expressed in primary oocyte otic placode otic vesicle saccule triceps brachii muscle sternocleidomastoid muscle extensor digitorum longus muscle temporal muscle medial ganglionic eminence plantaris muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding ATP binding ubiquitin conjugating enzyme activity ubiquitin protein ligase binding ubiquitin protein ligase activity ubiquitin-protein transferase activity Cellular component cytoplasm extracellular exosome cytosol Biological process protein K63-linked ubiquitination protein K48-linked ubiquitination ubiquitin-dependent protein catabolic process protein ubiquitination protein polyubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7326 67128 Ensembl ENSG00000132388 ENSMUSG00000020794 UniProt P62253 P62254 RefSeq (mRNA) NM_182682 NM_003342 NM_025985 RefSeq (protein) NP_003333 NP_080261 Location (UCSC) Chr 17: 4.27 – 4.37 Mb Chr 11: 72.5 – 72.58 Mb PubMed search [3] [4]
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins.^[6]