UBE2H

Ubiquitin-conjugating enzyme E2 H is a protein that in humans is encoded by the UBE2H gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesUBE2H, E2-20K, GID3, UBC8, UBCH, UBCH2, ubiquitin conjugating enzyme E2 H

External IDsOMIM: 601082; MGI: 104632; HomoloGene: 103894; GeneCards: UBE2H; OMA:UBE2H - orthologs

EC number2.3.2.24

Quick facts Available structures, PDB ...

UBE2H
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Z5D
Identifiers
Aliases	UBE2H, E2-20K, GID3, UBC8, UBCH, UBCH2, ubiquitin conjugating enzyme E2 H
External IDs	OMIM: 601082; MGI: 104632; HomoloGene: 103894; GeneCards: UBE2H; OMA:UBE2H - orthologs
EC number	2.3.2.24
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q32.2 Start 129,830,732 bp[1] End 129,952,960 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 A3.3|6 12.52 cM Start 30,211,288 bp[2] End 30,304,538 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte right adrenal cortex epithelium of colon saphenous vein internal globus pallidus Skeletal muscle tissue of biceps brachii amniotic fluid islet of Langerhans left adrenal gland caput epididymis Top expressed in blood retinal pigment epithelium Rostral migratory stream tibiofemoral joint substantia nigra medullary collecting duct ascending aorta ciliary body condyle fossa More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein binding ATP binding ubiquitin conjugating enzyme activity ubiquitin protein ligase binding ubiquitin protein ligase activity ubiquitin-protein transferase activity Cellular component cytoplasm cytosol Biological process protein K48-linked ubiquitination ubiquitin-dependent protein catabolic process proteasome-mediated ubiquitin-dependent protein catabolic process protein K11-linked ubiquitination protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7328 22214 Ensembl ENSG00000186591 ENSMUSG00000039159 UniProt P62256 P62257 RefSeq (mRNA) NM_001202498 NM_003344 NM_182697 NM_001169576 NM_001169577 NM_009459 RefSeq (protein) NP_001189427 NP_003335 NP_874356 NP_003335.1 NP_001163047 NP_001163048 NP_033485 Location (UCSC) Chr 7: 129.83 – 129.95 Mb Chr 6: 30.21 – 30.3 Mb PubMed search [3] [4]
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.^[6]