UBE2N

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Ubiquitin-conjugating enzyme E2 N is a protein that in humans is encoded by the UBE2N gene.[5][6]

PDBOrtholog search: PDBe RCSB
AliasesUBE2N, HEL-S-71, UBC13, UBCHBEN; UBC13, UbcH-ben, UbcH13, ubiquitin conjugating enzyme E2 N, UBCHBEN
Quick facts Available structures, PDB ...
UBE2N
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUBE2N, HEL-S-71, UBC13, UBCHBEN; UBC13, UbcH-ben, UbcH13, ubiquitin conjugating enzyme E2 N, UBCHBEN
External IDsOMIM: 603679; MGI: 1934835; HomoloGene: 128406; GeneCards: UBE2N; OMA:UBE2N - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003348

NM_080560

RefSeq (protein)

NP_003339

NP_542127

Location (UCSC)Chr 12: 93.41 – 93.44 MbChr 10: 95.35 – 95.38 Mb
PubMed search[3][4]
Wikidata
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Function

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair.[6]

Interactions

UBE2N has been shown to interact with:

References

Further reading

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