UBE2O

Ubiquitin-conjugating enzyme E2 O is a protein that in humans is encoded by the UBE2O gene.^[5][6][7]

AliasesUBE2O, E2-230K, ubiquitin conjugating enzyme E2 O

External IDsOMIM: 617649; MGI: 2444266; HomoloGene: 11113; GeneCards: UBE2O; OMA:UBE2O - orthologs

Chr.Chromosome 17 (human)^[1]

End76,453,152 bp^[1]

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UBE2O
Identifiers
Aliases	UBE2O, E2-230K, ubiquitin conjugating enzyme E2 O
External IDs	OMIM: 617649; MGI: 2444266; HomoloGene: 11113; GeneCards: UBE2O; OMA:UBE2O - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 76,389,456 bp[1] End 76,453,152 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 116,428,566 bp[2] End 116,472,273 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe apex of heart prefrontal cortex gastrocnemius muscle Brodmann area 9 ganglionic eminence stromal cell of endometrium islet of Langerhans right lobe of thyroid gland Top expressed in blood tibiofemoral joint primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell perirhinal cortex entorhinal cortex fetal liver hematopoietic progenitor cell CA3 field central gray substance of midbrain More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein binding ATP binding ubiquitin conjugating enzyme activity ubiquitin protein ligase binding ubiquitin protein ligase activity ubiquitin-protein transferase activity RNA binding Cellular component cytoplasm nucleus cytosol nuclear body Biological process positive regulation of BMP signaling pathway protein K63-linked ubiquitination retrograde transport, endosome to Golgi protein monoubiquitination protein ubiquitination transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 63893 217342 Ensembl ENSG00000175931 ENSMUSG00000020802 UniProt Q9C0C9 Q6ZPJ3 RefSeq (mRNA) NM_022066 NM_173755 RefSeq (protein) NP_071349 NP_776116 Location (UCSC) Chr 17: 76.39 – 76.45 Mb Chr 11: 116.43 – 116.47 Mb PubMed search [3] [4]
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UBE2O functions during terminal erythroid differentiation to eliminate generic cellular components in parallel with abundant synthesis of hemoglobin.^[8]