UCN2

Urocortin-2 is a protein that in humans is encoded by the UCN2 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesUCN2, SRP, UCN-II, UCNI, UR, URP, urocortin 2

External IDsOMIM: 605902; MGI: 2176375; HomoloGene: 50048; GeneCards: UCN2; OMA:UCN2 - orthologs

Chr.Chromosome 3 (human)^[1]

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UCN2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RMG, 3N95
Identifiers
Aliases	UCN2, SRP, UCN-II, UCNI, UR, URP, urocortin 2
External IDs	OMIM: 605902; MGI: 2176375; HomoloGene: 50048; GeneCards: UCN2; OMA:UCN2 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p21.31 Start 48,561,718 bp[1] End 48,563,781 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F2 Start 108,815,078 bp[2] End 108,816,232 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium testicle skin of abdomen skin of leg olfactory zone of nasal mucosa vagina prostate minor salivary glands ectocervix tibial nerve Top expressed in saccule otic vesicle otic placode blastocyst embryo muscle of thigh morula esophagus lip skin of external ear More reference expression data BioGPS n/a
Gene ontology Molecular function hormone binding G protein-coupled receptor binding corticotropin-releasing hormone receptor 2 binding hormone activity corticotropin-releasing hormone receptor binding Cellular component extracellular region extracellular space intracellular anatomical structure Biological process digestion cellular response to nutrient levels regulation of signaling receptor activity response to stress adenylate cyclase-activating G protein-coupled receptor signaling pathway hormone-mediated signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 90226 171530 Ensembl ENSG00000145040 ENSMUSG00000049699 UniProt Q96RP3 Q99ML8 RefSeq (mRNA) NM_033199 NM_145077 RefSeq (protein) NP_149976 NP_659543 Location (UCSC) Chr 3: 48.56 – 48.56 Mb Chr 9: 108.82 – 108.82 Mb PubMed search [3] [4]
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This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor (CRF) gene and the encoded product is an endogenous ligand for CRF type 2 receptors. In the brain it may be responsible for the effects of stress on appetite. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin II.^[6]