UGCG

Ceramide glucosyltransferase is an enzyme that in humans is encoded by the UGCG gene.^[5][6][7]

AliasesUGCG, GCS, GLCT1, UDP-glucose ceramide glucosyltransferase

External IDsOMIM: 602874; MGI: 1332243; HomoloGene: 37763; GeneCards: UGCG; OMA:UGCG - orthologs

Chr.Chromosome 9 (human)^[1]

End111,935,369 bp^[1]

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UGCG
Identifiers
Aliases	UGCG, GCS, GLCT1, UDP-glucose ceramide glucosyltransferase
External IDs	OMIM: 602874; MGI: 1332243; HomoloGene: 37763; GeneCards: UGCG; OMA:UGCG - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q31.3 Start 111,896,814 bp[1] End 111,935,369 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 32.44 cM|4 B3 Start 59,189,257 bp[2] End 59,222,833 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of thigh bronchial epithelial cell jejunal mucosa vena cava trabecular bone epithelium of nasopharynx pericardium cartilage tissue buccal mucosa cell bone marrow Top expressed in decidua morula morula gastrula esophagus lymph node jejunum tail of embryo ileum secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glycosyltransferase activity transferase activity ceramide glucosyltransferase activity dihydroceramide glucosyltransferase activity protein binding Cellular component integral component of membrane Golgi membrane Golgi apparatus membrane Biological process glycosphingolipid biosynthetic process glycosphingolipid metabolic process glucosylceramide biosynthetic process epidermis development lipid metabolism sphingolipid metabolic process cell differentiation neuron development establishment of skin barrier intestinal lipid absorption protein lipidation regulation of signal transduction keratinocyte differentiation leptin-mediated signaling pathway cornified envelope assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7357 22234 Ensembl ENSG00000148154 ENSMUSG00000028381 UniProt Q16739 O88693 RefSeq (mRNA) NM_003358 NM_011673 RefSeq (protein) NP_003349 NP_003349.1 NP_035803 Location (UCSC) Chr 9: 111.9 – 111.94 Mb Chr 4: 59.19 – 59.22 Mb PubMed search [3] [4]
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Glycosphingolipids (GSLs) are a group of membrane components that contain lipid and sugar moieties. They are present in essentially all animal cells and are believed to have important roles in various cellular processes. UDP-glucose ceramide glucosyltransferase catalyzes the first glycosylation step in glycosphingolipid biosynthesis. The product, glucosylceramide, is the core structure of more than 300 GSLs. UGCG is widely expressed and transcription is upregulated during keratinocyte differentiation.^[7]