ULBP1

ULBP1
Identifiers
Aliases	ULBP1, RAET1I, N2DL-1, NKG2DL1, UL16 binding protein 1
External IDs	OMIM: 605697; MGI: 1925027; HomoloGene: 108274; GeneCards: ULBP1; OMA:ULBP1 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	149,973,715 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	7,423,638 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; pancreatic ductal cell; ; right lung; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; upper lobe of left lung; ; islet of Langerhans; ; ventricular zone; ; ganglionic eminence; ; right testis;
	Top expressed in
	thymus; ; yolk sac; ; granulocyte; ; spermatocyte; ; secondary oocyte; ; placenta; ; embryo; ; epiblast; ; primary oocyte; ; embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	natural killer cell lectin-like receptor binding; protein binding;
Cellular component	anchored component of membrane; anchored component of plasma membrane; endoplasmic reticulum; membrane; cytosol; plasma membrane; actin cytoskeleton; extracellular space; external side of plasma membrane;
Biological process	natural killer cell activation; natural killer cell mediated cytotoxicity; regulation of immune response; immune system process; viral process; T cell mediated cytotoxicity; immune response; susceptibility to natural killer cell mediated cytotoxicity;
	Sources:Amigo / QuickGO
Orthologs
	80329
	77777
	ENSG00000111981
	ENSMUSG00000079685
	Q9BZM6
	n/a
	NM_025218; NM_001317089
	NM_029975
	NP_001304018; NP_079494
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

UL16 binding protein 1 (ULBP1) is a cell surface glycoprotein encoded by ULBP1 gene located on the chromosome 6.^[5]^[6] ULBP1 is related to MHC class I molecules, but its gene maps outside the MHC locus.^[5]^[6] The domain structure of ULBP1 differs significantly from those of conventional MHC class I molecules. It does not contain the α3 domain and the transmembrane segment. ULBP1 is thus composed of only the α1α2 domain which is linked to the cell membrane by the GPI anchor.^[5]^[6] It functions as a stress-induced ligand for NKG2D receptor.^[5] ULBP1 is, for example, upregulated during HCMV infection.^[7] Binding of HCMV-encoded UL16 glycoprotein to ULBP1 interferes with cell surface localization of ULBP1; this represents another mechanism by which HCMV-infected cells might escape the immune system.^[7]