ULBP3

ULBP3
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	1KCG
Identifiers
Aliases	ULBP3, RAET1N, N2DL-3, NKG2DL3, UL16 binding protein 3
External IDs	OMIM: 605699; HomoloGene: 129737; GeneCards: ULBP3; OMA:ULBP3 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	150,069,121 bp
RNA expression pattern
	Top expressed in
	testicle; ; pancreatic epithelial cell; ; cartilage tissue; ; stromal cell of endometrium; ; gingival epithelium; ; tibia; ; gonad; ; ventricular zone; ; islet of Langerhans; ; retinal pigment epithelium;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	natural killer cell lectin-like receptor binding; protein binding;
Cellular component	anchored component of membrane; anchored component of plasma membrane; plasma membrane; membrane; extracellular space; external side of plasma membrane;
Biological process	natural killer cell activation; viral process; natural killer cell mediated cytotoxicity; regulation of immune response; immune system process; T cell mediated cytotoxicity; immune response; susceptibility to natural killer cell mediated cytotoxicity;
	Sources:Amigo / QuickGO
Orthologs
	79465
	n/a
	ENSG00000131019
	n/a
	Q9BZM4
	n/a
	NM_024518
	n/a
	NP_078794
	n/a
	Wikidata
View/Edit Human

UL16 binding protein 3 (ULBP3) is a cell surface glycoprotein encoded by ULBP3 gene located on the chromosome 6.^[3]^[4] ULBP3 is related to MHC class I molecules, but its gene maps outside the MHC locus.^[3]^[4] The domain structure of ULBP3 differs significantly from those of conventional MHC class I molecules. It does not contain the α3 domain and the transmembrane segment. ULBP3 is thus composed of only the α1α2 domain which is linked to the cell membrane by the GPI anchor.^[3]^[4] It functions as a stress-induced ligand for NKG2D receptor.^[3]