UNC13B
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Protein unc-13 homolog B is a protein that in humans is encoded by the UNC13B gene[5][6] and in mice by the Munc13-2 gene [7]
Function
This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis.[6]
