UNC5C

Netrin receptor UNC5C is a protein that in humans is encoded by the UNC5C gene.^[5][6][7]

AliasesUNC5C, UNC5H3, unc-5 netrin receptor C

External IDsOMIM: 603610; MGI: 1095412; HomoloGene: 2765; GeneCards: UNC5C; OMA:UNC5C - orthologs

Chr.Chromosome 4 (human)^[1]

End95,549,206 bp^[1]

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UNC5C
Identifiers
Aliases	UNC5C, UNC5H3, unc-5 netrin receptor C
External IDs	OMIM: 603610; MGI: 1095412; HomoloGene: 2765; GeneCards: UNC5C; OMA:UNC5C - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q22.3 Start 95,162,504 bp[1] End 95,549,206 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 H1|3 65.57 cM Start 141,170,977 bp[2] End 141,540,685 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus callosum tibia internal globus pallidus pons inferior ganglion of vagus nerve subthalamic nucleus testicle right coronary artery C1 segment superior vestibular nucleus Top expressed in genital tubercle secondary oocyte supraoptic nucleus zygote otic vesicle ethmoid bone suprachiasmatic nucleus ascending aorta cerebellar vermis cribriform plate More reference expression data BioGPS More reference expression data
Gene ontology Molecular function netrin receptor activity netrin receptor activity involved in chemorepulsion protein binding protein kinase binding tubulin binding Cellular component integral component of membrane neuron projection cell junction plasma membrane synapse membrane axon dendrite growth cone soma lamellipodium filopodium cell surface cell projection Biological process positive regulation of apoptotic process netrin-activated signaling pathway multicellular organism development brain development regulation of cell migration signal transduction anterior/posterior axon guidance axon guidance apoptotic process negative chemotaxis chemorepulsion of axon dorsal root ganglion development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8633 22253 Ensembl ENSG00000182168 ENSMUSG00000059921 UniProt O95185 O08747 RefSeq (mRNA) NM_003728 NM_001293561 NM_009472 RefSeq (protein) NP_003719 NP_001280490 NP_033498 Location (UCSC) Chr 4: 95.16 – 95.55 Mb Chr 3: 141.17 – 141.54 Mb PubMed search [3] [4]
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This gene product belongs to the UNC-5 family of netrin receptors. Netrins are secreted proteins that direct axon extension and cell migration during neural development. They are bifunctional proteins that act as attractants for some cell types and as repellents for others, and these opposite actions are thought to be mediated by two classes of receptors. The UNC-5 family of receptors mediate the repellent response to netrin; they are transmembrane proteins containing 2 immunoglobulin (Ig)-like domains and 2 type I thrombospondin motifs in the extracellular region.^[7]