UPF1
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Regulator of nonsense transcripts 1 (or Up-frameshift suppressor 1 homolog[5]) is a protein that in humans is encoded by the UPF1 gene.[6][7]
Function
This gene encodes a protein that is part of a post-splicing multiprotein complex, the exon junction complex, involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in both the cytoplasm and nucleus.[8] When translation ends, it interacts with the functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.[9]
