UPF3B

Regulator of nonsense transcripts 3B is a protein that in humans is encoded by the UPF3B gene.^[5][6][7]

PDBHuman UniProt search: PDBe RCSB

AliasesUPF3B, HMRX62, MRXS14, RENT3B, UPF3X, Upf3p-X, UPF3BP1, UPF3BP2, UPF3BP3, UPF3 regulator of nonsense transcripts homolog B (yeast), UPF3 regulator of nonsense transcripts homolog B, regulator of nonsense mediated mRNA decay, UPF3B regulator of nonsense mediated mRNA decay, MRX82

External IDsOMIM: 300298; MGI: 1915384; HomoloGene: 11307; GeneCards: UPF3B; OMA:UPF3B - orthologs

Chr.X chromosome (human)^[1]

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UPF3B
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 1UW4, 2XB2
Identifiers
Aliases	UPF3B, HMRX62, MRXS14, RENT3B, UPF3X, Upf3p-X, UPF3BP1, UPF3BP2, UPF3BP3, UPF3 regulator of nonsense transcripts homolog B (yeast), UPF3 regulator of nonsense transcripts homolog B, regulator of nonsense mediated mRNA decay, UPF3B regulator of nonsense mediated mRNA decay, MRX82
External IDs	OMIM: 300298; MGI: 1915384; HomoloGene: 11307; GeneCards: UPF3B; OMA:UPF3B - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq24 Start 119,805,311 bp[1] End 119,852,998 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A3.3 Start 37,091,678 bp[2] End 37,110,322 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve embryo cerebellar hemisphere ganglionic eminence endothelial cell amniotic fluid right hemisphere of cerebellum ventricular zone testicle visceral pleura Top expressed in Ileal epithelium Paneth cell neural layer of retina pineal gland medullary collecting duct retinal pigment epithelium epithelium of lens islet of Langerhans fossa substantia nigra More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding mRNA binding structural constituent of nuclear pore nucleic acid binding RNA binding Cellular component exon-exon junction complex nucleoplasm microtubule organizing center nucleolus nucleus cytoplasm cytosol Biological process mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA transport mRNA export from nucleus positive regulation of translation nuclear-transcribed mRNA catabolic process, nonsense-mediated decay mRNA 3'-end processing RNA export from nucleus transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 65109 68134 Ensembl ENSG00000125351 ENSMUSG00000036572 UniProt Q9BZI7 n/a RefSeq (mRNA) NM_023010 NM_080632 NM_026573 RefSeq (protein) NP_075386 NP_542199 n/a Location (UCSC) Chr X: 119.81 – 119.85 Mb Chr X: 37.09 – 37.11 Mb PubMed search [3] [4]
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This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome X. Two splice variants encoding different isoforms have been found for this gene.^[7]