UR-AK49

UR-AK49 is a drug used in scientific research which acts as a potent antagonist for the Neuropeptide Y / Pancreatic polypeptide receptor Y₄, and also as a partial agonist at the histamine receptors H₁ and H₂.^[1] UR-AK49 is a pure antagonist at Y₄ with no partial agonist effects, and although it is only slightly selective for Y₄ over the related Y₁ and Y₅ receptors, as the first non-peptide Y₄ antagonist developed UR-AK49 is expected to be useful in the study of this receptor and its role in the body.^[2]

Other namesUR-AK49

CAS Number

• 902154-32-9 ^Y

PubChem CID

• 25149433

ChemSpider

• 21486130 ^Y

Quick facts Clinical data, Other names ...

UR-AK49

Clinical data
Other names	UR-AK49
Identifiers
IUPAC name 3-cyclohexyl-N-[N'-[3-(1H-imidazol-5-yl)propyl]carbamimidoyl]propanamide
CAS Number	902154-32-9 Y
PubChem CID	25149433
ChemSpider	21486130 Y
UNII	5HML8P3QAT
ChEMBL	ChEMBL486974 Y
CompTox Dashboard (EPA)	DTXSID701028442
Chemical and physical data
Formula	C16H27N5O
Molar mass	305.426 g·mol−1
3D model (JSmol)	Interactive image
SMILES c1c(nc[nH]1)CCCNC(=N)NC(=O)CCC2CCCCC2
InChI InChI=1S/C16H27N5O/c17-16(19-10-4-7-14-11-18-12-20-14)21-15(22)9-8-13-5-2-1-3-6-13/h11-13H,1-10H2,(H,18,20)(H3,17,19,21,22) Y Key:QBGKYFYOFBXHFM-UHFFFAOYSA-N Y
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