USF2

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Upstream stimulatory factor 2 is a protein that in humans is encoded by the USF2 gene.[5][6]

AliasesUSF2, FIP, bHLHb12, upstream transcription factor 2, c-fos interacting
End35,279,821 bp[1]
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USF2
Identifiers
AliasesUSF2, FIP, bHLHb12, upstream transcription factor 2, c-fos interacting
External IDsOMIM: 600390; MGI: 99961; HomoloGene: 2527; GeneCards: USF2; OMA:USF2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003367
NM_207291
NM_001321150

NM_011680

RefSeq (protein)

NP_001308079
NP_003358
NP_997174

NP_035810

Location (UCSC)Chr 19: 35.27 – 35.28 MbChr 7: 30.64 – 30.66 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a member of the basic helix-loop-helix leucine zipper family, and can function as a cellular transcription factor. The encoded protein can activate transcription through Pyridine-rich initiator (Inr) elements and E-box motifs. Two transcript variants encoding distinct isoforms have been identified for this gene.[6]

Interactions

USF2 has been shown to interact with USF1 (human gene),[7][8] PPRC1[9] and BRCA1.[10]

Regulation

The USF2 gene is repressed by the microRNA miR-10a.[11]

References

Further reading

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