USP36

Ubiquitin-specific protease 36 is an enzyme that in humans is encoded by the USP36 gene. ^{[5] [6]}

AliasesUSP36, DUB1, ubiquitin specific peptidase 36

External IDsOMIM: 612543; MGI: 1919594; HomoloGene: 11828; GeneCards: USP36; OMA:USP36 - orthologs

Chr.Chromosome 17 (human)^[1]

End78,841,441 bp^[1]

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USP36
Identifiers
Aliases	USP36, DUB1, ubiquitin specific peptidase 36
External IDs	OMIM: 612543; MGI: 1919594; HomoloGene: 11828; GeneCards: USP36; OMA:USP36 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 78,787,381 bp[1] End 78,841,441 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 118,150,477 bp[2] End 118,181,070 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve anterior pituitary left ovary right ovary left uterine tube body of pancreas right hemisphere of cerebellum skin of leg skin of abdomen gastric mucosa Top expressed in Rostral migratory stream zygote genital tubercle primitive streak neural layer of retina tail of embryo lacrimal gland muscle of thigh epiblast otic vesicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function thiol-dependent deubiquitinase peptidase activity cysteine-type peptidase activity hydrolase activity RNA binding Cellular component nucleolus nucleus nuclear speck Biological process protein deubiquitination regulation of autophagy of mitochondrion ubiquitin-dependent protein catabolic process positive regulation of protein targeting to mitochondrion proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57602 72344 Ensembl ENSG00000055483 ENSMUSG00000033909 UniProt Q9P275 B1AQJ2 RefSeq (mRNA) NM_025090 NM_001321291 NM_001033528 RefSeq (protein) NP_001308220 NP_001028700 Location (UCSC) Chr 17: 78.79 – 78.84 Mb Chr 11: 118.15 – 118.18 Mb PubMed search [3] [4]
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This gene encodes a member of the ubiquitin-specific protease family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the nucleoli and deubiquitinate nucleophosmin and fibrillarin^[7]