USP8

USP8
Identifiers
Aliases	USP8, HumORF8, SPG59, UBPY, ubiquitin specific peptidase 8, PITA4
External IDs	OMIM: 603158; MGI: 1934029; GeneCards: USP8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WHB, 2A9U, 2GFO, 2GWF, 3N3K
Enzyme activity
Gene location (Human)
Chr.	Chromosome 15 (human)
End	50,514,421 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	126,601,217 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; sural nerve; ; epithelium of colon; ; ventricular zone; ; testicle; ; rectum; ; monocyte; ; caput epididymis; ; corpus epididymis; ; gallbladder;
	Top expressed in
	spermatid; ; seminiferous tubule; ; spermatocyte; ; tail of embryo; ; genital tubercle; ; right kidney; ; stroma of bone marrow; ; zygote; ; deep cerebellar nuclei; ; medial vestibular nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	cysteine-type peptidase activity; SH3 domain binding; thiol-dependent deubiquitinase; peptidase activity; protein binding; cysteine-type endopeptidase activity; hydrolase activity; cadherin binding;
Cellular component	cytoplasm; endosome; membrane; plasma membrane; extrinsic component of endosome membrane; midbody; endosome membrane; extrinsic component of plasma membrane; nucleus; postsynaptic density; dendritic spine; early endosome; cytosol; glutamatergic synapse;
Biological process	protein K48-linked deubiquitination; ubiquitin-dependent protein catabolic process; mitotic cytokinesis; endosome organization; proteolysis; protein K63-linked deubiquitination; cell cycle; cell population proliferation; protein deubiquitination; cellular response to dexamethasone stimulus; cellular response to nerve growth factor stimulus; positive regulation of canonical Wnt signaling pathway; Ras protein signal transduction; regulation of protein stability; regulation of protein localization; regulation of protein catabolic process at postsynapse, modulating synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9101
	84092
	ENSG00000138592
	ENSMUSG00000027363
	P40818
	Q80U87
	NM_001128610; NM_001128611; NM_001283049; NM_005154
	NM_001252580; NM_019729
	NP_001122082; NP_001269978; NP_005145
	NP_001239509; NP_062703
	Wikidata
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