User:BetsyRogers
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Me
Expertise:
Available to assist as subject matter expert for articles pertaining to:
- Science (general), biology, zoology
- Genetics (incl, molecular biology, human genetics, medical genetics, genetic testing, phamacogenomics).
- Biochemistry (incl. enzymology, protein chemistry, pharmacodynamics)
- DNA, RNA, proteins (interactions, gene regulation, transcription, replication, DNA damage & repair).
- Marine biology (incl. marine vertebrates & invertebrates, marine ecosystems, estuarial ecosystems, crustacean endocrinology - yeah, that's a thing)
- Healthcare policy, regulatory compliance (incl. FDA, HIPAA)
Other:
Able to assist, but not formally a subject matter "expert":
- Languages (incl. etymology, linguistics)
- Women's history, Women in STEM
- United States: civil rights, voting rights, election law, campaign finance law, healthcare reform
Gallery
Underappreciated wildlife:
Because "building a structure and decorating it with sticks and brightly coloured objects to attract a mate" isn't as easy as it sounds.
Images to upload:
Miscellaneous
I really think this sign will help.- "It's okay to not like things"
Search Tools
Advanced Search: Special:Search
Journal Search at Wikipedia Library: (incl Nature, AAAS, JAMA,
Open Access Images Search:
- Creative Commons Search Portal
- WikiCommons free media resources (photos)
- Flickr Creative-Commons licensed
- Smithsonian Open Access (usage guidelines)
- NOAA photo library (images only)
- NASA Images (usage guidelines )
- OpenStax (usage guidelines)
- Kahn Academy
- Metropolitan Museum of Art
Guides
Cleanup
Cleanup |
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Cleanup (main): Wikipedia:Cleanup Categorization
Redirect templatesWikipedia:Template index/Redirect pages
Stub sorting
Orphan ArticlesOrphan tag/template: "Please add articles to this category by using {{Orphan}} "Please note that some of these articles may have been de-orphaned, or tagged with an {{orphan}} template, since this list was last updated."
Copy Edit
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To Do #1
To Do #1 |
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Fix categories in Bacteriosin articles. (See Bacteriocin main article, "list by name" section, has links to specific bacteriocins) Add narrow, specific categories:
REMOVE parent categories if redundant Add stub tags where needed:
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To Do #2
To Do #2 |
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- add Further Reading section - secondary refs to clinical trials - give rationale for considering Esmethadone for treatment-resistant depression (NMDA receptor affinity with low mu-receptor affinity) - check chembox; add pharma box if needed.
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To Do, misc
To Do #2 |
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Make to-do list in new page/sandbox. (Find template for checklist format) Find standalone box/button for shortcuts? e.g.: watchlist, category search, stub category search, reliable sources, Userbox directory Direct* links to action items pages in WikiProjects |
WikiProjects
Guides
Guides |
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User pages: Colors: Misc: |
Templates
Templates |
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TemplatesUser boxes
User pages
Article Templates
For x see y: More citations needed (article): Unreferenced medical section Unreliable medical source (no box) [unreliable medical source?] Disputed |
Sandboxes
Editing⤵️
Editing |
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Epigenetic clock outline Epigenetic Clock outline: Lede:(include short sentence on applications: research on aging, longevity, chronic diseases, and certain cancers) Background (scientific background):Epigenetics and aging:- concept of epigenetics (example, methylation) - concept of biomarkers of aging (example telomere length, histones, methylation) - motivation for epigenetic clock - existing section
Epigenetic clocks (general concept):- explain why methylation lends itself well to development of an epigenetic clock - briefly, specific genes typically used for readout on DNAm levels as related to aging (& why) - brief statement of 1st gen, 2nd gen, 3rd gen, & other types of clocks History(edit existing section) - Hx of epigenetics major findings - Discovery of epigenetic changes that correlate with aging and some diseases. - Methylation-based Epigenetic clocks1st generation - Horvath, Hannum (explain individually) - include: method (incl genes used), applications, computer algorithm used, advantages vs previous options, limitations) 2nd generation - Levine, - method & genes, applications, advantages, algorithm, limitations as above, including compare/contrast to 1st gen. 3rd gen & others - same as above - include clocks using other markers (i.e., not methylation Practical applications(?)- include limitations of current methods (collectively) - currently only used for research purposes, for studies related to aging & diseases. - examples of applications (in existing section) Future directions:- beyond methylation clocks (e.g. histones) - potential use as clinical test? (re overall health/risks, or re disease states) and medical interventions - increasing lifespan may be farther away but improving quality of life (e.g. chronic disease) is within reach. Also see: Epigenetics |
Editing |
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Editing⬇️(Excerpts, drafts) Epigenetic clockAdd "under construction" message box template Article: Epigenetic clock Sandbox: https://en.wikipedia.org/wiki/User:BetsyRogers/sandbox2 Epigenetic clock: - Add section to reflect other epigenetic clocks from other groups - add sections organized by to 1st-gen, 2nd-gen, 3rd-gen, & "other". - Find open-access infographic explaining epigenetic clock, or at least showing CpG methylation w/age. - More secondary sources (reviews) - Cleanup informal language - move/delete biographical text (move to corresponding biographical article? or get consensus to delete) - update with new developments in field - reorganize headings to facilitate future expansion of article (easy to update with new developments). - organize the section just listing research findings
- Horvath’s Clock (2011 or 2013?): 2011:"Epigenetic Predictor of Age" Bocklandt et al. PLoS One. 2011. https://pubmed.ncbi.nlm.nih.gov/21731603/ (https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0014821) 2013: "DNA methylation age of human tissues and cell types". BMC Genome Biology (Dec 2013). https://genomebiology.biomedcentral.com/articles/10.1186/gb-2013-14-10-r115 - Hannum’s Clock (2013): Hannum et al, "Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates". Molecular Cell (January 2013). https://www.cell.com/molecular-cell/fulltext/S1097-2765(12)00893-3
Nooh Bocklandt (2011), Skin & Blood Clock (Horvath 2018). refs: Belsky 2015?
ref: An epigenetic biomarker of aging for lifespan and healthspan (Levine et al, 2018) https://pubmed.ncbi.nlm.nih.gov/29676998/
Belsky measures the pace of epigenetic aging rather than a static age in DunedinPACE
Causality-enriched clocks: CausAge, AdaptAge, and DamAge Neural network-based models (e.g., DeepMAge, AltumAge) Ancestry cohorts (e.g., iCAS-DNAmAge =Chinese populations)
Reviews (chronological) Epigenetic clock: A promising biomarker and practical tool in aging Ageing Res Rev (2022 Nov) https://pubmed.ncbi.nlm.nih.gov/36206857/ (https://www.sciencedirect.com/science/article/abs/pii/S1568163722001854) The use of DNA methylation clock in aging research" (2020 Nov) https://pmc.ncbi.nlm.nih.gov/articles/PMC7885055/ What Are Epigenetic Clocks and Their Role in Aging Research https://federalhealthgroup.com/posts/what-are-epigenetic-clocks-and-their-role-in-aging-research/ Using Epigenetic Clocks to Characterize Biological Aging in Studies of Children and Childhood Exposures: a Systematic Review https://pmc.ncbi.nlm.nih.gov/articles/PMC10964791/#R53 Epigenetic clocks and programmatic aging Exploring the correlation between DNA methylation and biological age using an interpretable machine learning framework https://www.sciencedirect.com/science/article/pii/S1568163724003647 A systematic review of phenotypic and epigenetic clocks used for aging and mortality quantification in humans https://pmc.ncbi.nlm.nih.gov/articles/PMC11424583/ See Table 1, "Table 1. Descriptive statistics of all included first-generation epigenetic clocks." -- Big table listing several clocks) Comprehensive analysis of epigenetic clocks reveals associations between disproportionate biological ageing and hippocampal volume https://pmc.ncbi.nlm.nih.gov/articles/PMC9213584/ Epigenetic ageing clocks: statistical methods and emerging computational challenges https://www.nature.com/articles/s41576-024-00807-w DNA methylation of the ELOVL2, FHL2, KLF14, C1orf132/MIR29B2C, and TRIM59 genes for age prediction from blood, saliva, and buccal swab samples https://www.fsigenetics.com/article/S1872-4973(18)30238-2/abstract Methylclock - DNA methylation-based clocks https://www.bioconductor.org/packages/release/bioc/html/methylclock.html methylclock software pkg https://isglobal-brge.github.io/methylclock/index.html "methylclock package allows to estimate chronological and gestational DNA methylation (DNAm) age as well as biological age using different methylation clocks. The package includes the following estimators..." (tech specs on a *lot* of clocks) "Universal DNA methylation age across mammalian tissues" Nat Aging, Aug 2023. https://pmc.ncbi.nlm.nih.gov/articles/PMC10501909/ |
Editing |
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Editing⬇️
PharmacodynamicsPharmacodynamics. Cleanup biophysics terms (definitions, methods), add citations.
Pharmacology outlineTitle: Pharmacology Overview(Definition, etc) EtymologyHistoryOrigins of Pharmacology ( ___ B.C.)18th & 19th centuriesModern Pharmacology-pharmacology research, general info small paragraph -medical applications, general general info Scientific Principles of Pharmacologyoverviewincl background knowledge fields, e.g organic chem, biochem, cell bio, synthetic chem? etc) drug mechanism of actionpharmacodynamicspharmacokineticstoxicologypharmacogenomicsMedical Pharmacology, Therapeuticsoverviewapplied pharmacology, i.e. relates to pharmacy practice, medical practice, clinical trials drug classification-chemical class (can apply to multiple organ systems) -organ systems (can include multiple drug classes) -disease types (can impact multiple organ systems and include multiple drug classes) patient safety-drug toxicity (mechanisms, signs, and risk factors) -drug interactions (drug-drug, drug-food, drug-supplement) -drug dependency Drug Discovery, Drug DevelopmentoverviewDrug designPreclinical research & developmentClinical research, clinical trialsDrug SafetyDrug EfficacyRegulatory oversightEmerging fields-e.g., drugs + gut microbiome External Sourceshttps://www.britannica.com/science/pharmacology https://www.merckmanuals.com/home/drugs/drug-dynamics/drug-action https://www.bumc.bu.edu/ppb/pharmacology-glossary/ |
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Editing⬇️Oxygen cocktailRfD? Oxygen cocktail: clarify this is *not* a medical treatment, address misinformation. Anti-inflammatoryAnti-inflammatory |