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Scrambler therapy (or Calmare scramber therapy or Calmare therapy), like transcutaneous electrical nerve stimulation (TENS), involves the use of an electric current produced by a device to stimulate the nerves for therapeutic purposes. However, there are important distinctions. The device must be used by a trained specialist. There are no known adverse or side effects with normal use.

It was invented by Giuseppe Marineo at the University of Rome Tor Vergata.[1] The first research paper into its effectiveness was in 2000.[2] The device used is a Calmare MC5-A device. It has been FDA-cleared 510(k)-cleared and European CE mark-certified.[3]

This device has been shown to be effective in the treatment of:

Treatment is adminstered as follows:[12]

  • mixed or neuropathic pain - 10/12 consecutive treatments of 30 or 45 minutes; once a day for five days a week.
  • cancer pain - initial treatment program consisting of 10/12 consecutive treatments of 45 minutes, once a day, and every time the pain reappears. Analgesia on patient request.

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