VAMP1

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP1 is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Multiple alternative splice variants that encode proteins with alternative carboxy ends have been described, but the full-length nature of some variants has not been defined.^[6]

Homozygous mutations in VAMP1 have been identified in a series of children affected with a form of congenital myasthenic syndrome and similar presynaptic features in these patients and the knock-out VAMP1 mouse have been demonstrated.^[7]

VAMP1 expression has been linked to higher survival rates for lung cancer patients.^[8]

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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Nicotine Activity on Dopaminergic Neurons edit

1. [1]

   The interactive pathway map can be edited at WikiPathways: "NicotineDopaminergic_WP1602".