VPS11

VPS11
Identifiers
Aliases	VPS11, END1, PEP5, RNF108, hHLD12, CORVET/HOPS core subunit, VPS11 core subunit of CORVET and HOPS complexes
External IDs	OMIM: 608549; MGI: 1918982; HomoloGene: 6673; GeneCards: VPS11; OMA:VPS11 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	119,081,978 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	44,272,967 bp
RNA expression pattern
	Top expressed in
	prefrontal cortex; ; pituitary gland; ; apex of heart; ; right frontal lobe; ; anterior pituitary; ; right hemisphere of cerebellum; ; right adrenal gland; ; primary visual cortex; ; putamen; ; right adrenal cortex;
	Top expressed in
	interventricular septum; ; granulocyte; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; primary visual cortex; ; ankle; ; muscle of thigh; ; cerebellar cortex; ; right kidney;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; protein-macromolecule adaptor activity; protein domain specific binding; metal ion binding; protein binding; syntaxin binding;
Cellular component	HOPS complex; endosome; late endosome; late endosome membrane; membrane; endocytic vesicle; autophagosome; lysosomal membrane; early endosome; lysosome; cytoplasmic vesicle; clathrin-coated vesicle;
Biological process	endosomal vesicle fusion; regulation of protein stability; regulation of organelle assembly; positive regulation of protein targeting to mitochondrion; endosome to lysosome transport; autophagy; positive regulation of early endosome to late endosome transport; protein transport; intracellular protein transport; vesicle-mediated transport; regulation of SNARE complex assembly; lysosome organization; endosome organization; vesicle docking involved in exocytosis; transport;
	Sources:Amigo / QuickGO
Orthologs
	55823
	71732
	ENSG00000160695; ENSG00000280616
	ENSMUSG00000032127
	Q9H270
	Q91W86
	NM_001290185; NM_021729
	NM_027889; NM_001357393
NP_001277114; NP_068375; NP_001365147; NP_001365148; NP_001365149;
	NP_001365150
	NP_082165; NP_001344322
	Wikidata
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