VPS18

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Vacuolar protein sorting-associated protein 18 homolog is a protein that in humans is encoded by the VPS18 gene.[5][6][7]

AliasesVPS18, PEP3, CORVET/HOPS core subunit, VPS18 core subunit of CORVET and HOPS complexes
End40,903,975 bp[1]
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VPS18
Identifiers
AliasesVPS18, PEP3, CORVET/HOPS core subunit, VPS18 core subunit of CORVET and HOPS complexes
External IDsOMIM: 608551; MGI: 2443626; HomoloGene: 13302; GeneCards: VPS18; OMA:VPS18 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_020857

NM_172269

RefSeq (protein)

NP_065908
NP_065908.1

NP_758473

Location (UCSC)Chr 15: 40.89 – 40.9 MbChr 2: 119.12 – 119.13 Mb
PubMed search[3][4]
Wikidata
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Function

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway.[7]

Interactions

VPS18 has been shown to interact with VPS11[8] and STX7.[8]

References

Further reading

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