VPS24

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Charged multivesicular body protein 3 is a protein that in humans is encoded by the VPS24 gene.[5][6][7]

PDBOrtholog search: PDBe RCSB
AliasesCHMP3, NEDF, VPS24, CGI-149, charged multivesicular body protein 3
Quick facts CHMP3, Available structures ...
CHMP3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCHMP3, NEDF, VPS24, CGI-149, charged multivesicular body protein 3
External IDsOMIM: 610052; MGI: 1913950; HomoloGene: 6368; GeneCards: CHMP3; OMA:CHMP3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001005753
NM_001193517
NM_016079

NM_025783
NM_001355674
NM_001355675
NM_001361405

RefSeq (protein)

NP_001005753
NP_001180446
NP_057163

NP_080059
NP_001342603
NP_001342604
NP_001348334

Location (UCSC)Chr 2: 86.5 – 86.56 MbChr 6: 71.52 – 71.56 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a protein that acts in the sorting of transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants encoding different isoforms.[7]

Interactions

VPS24 has been shown to interact with IGFBP7.[5]

References

Further reading

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