VPS52

Vacuolar protein sorting-associated protein 52 homolog is a protein that in humans is encoded by the VPS52 gene.^[5][6]

AliasesVPS52, ARE1, SAC2, SACM2L, dJ1033B10.5, GARP complex subunit, VPS52 subunit of GARP complex

External IDsOMIM: 603443; MGI: 1330304; HomoloGene: 5756; GeneCards: VPS52; OMA:VPS52 - orthologs

Chr.Chromosome 6 (human)^[1]

End33,272,047 bp^[1]

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VPS52
Identifiers
Aliases	VPS52, ARE1, SAC2, SACM2L, dJ1033B10.5, GARP complex subunit, VPS52 subunit of GARP complex
External IDs	OMIM: 603443; MGI: 1330304; HomoloGene: 5756; GeneCards: VPS52; OMA:VPS52 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 33,250,272 bp[1] End 33,272,047 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 34,174,786 bp[2] End 34,186,009 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland right uterine tube pituitary gland right adrenal cortex left lobe of thyroid gland right hemisphere of cerebellum spleen anterior pituitary left adrenal cortex right ovary Top expressed in granulocyte superior frontal gyrus primary visual cortex muscle of thigh lip spermatocyte neural layer of retina dentate gyrus of hippocampal formation granule cell right kidney Ileal epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function syntaxin binding protein binding Cellular component perinuclear region of cytoplasm recycling endosome EARP complex endosome Golgi apparatus endosome membrane membrane trans-Golgi network membrane GARP complex cytosol Biological process protein transport ectodermal cell differentiation embryonic ectodermal digestive tract development endocytic recycling lysosomal transport Golgi to vacuole transport retrograde transport, endosome to Golgi Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6293 224705 Ensembl ENSG00000236014 ENSG00000206286 ENSG00000223501 ENSG00000224455 ENSG00000225590 ENSG00000223618 ENSG00000228425 ENSMUSG00000024319 UniProt Q8N1B4 Q8C754 RefSeq (mRNA) NM_001289174 NM_001289175 NM_001289176 NM_022553 NM_172620 NM_001357329 NM_001357330 NM_001379410 NM_001379411 RefSeq (protein) NP_001276103 NP_001276104 NP_001276105 NP_072047 NP_766208 NP_001344258 NP_001344259 NP_001366339 NP_001366340 Location (UCSC) Chr 6: 33.25 – 33.27 Mb Chr 17: 34.17 – 34.19 Mb PubMed search [3] [4]
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This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18.^[6]