VqmR sRNA
RNA family
From Wikipedia, the free encyclopedia
VqmR small RNA was discovered in Vibrio cholerae, a bacterium which can cause cholera, using differential RNA sequencing (sRNA-seq) under conditions of low and high cell density which were being used to study quorum sensing (QS).[1] QS controls virulence and biofilm formation in Vibrio cholerae; it has been shown previously that it is directed by the Qrr sRNAs.[2][3] VqmR has been shown to repress the expression of multiple mRNAs including the rtx (repeats in toxin) toxin genes and the vpsT , which is required for biofilm formation. In fact, VqmR which is highly conserved in vibrionaceae, was shown to strongly inhibit biofilm formation by repressing the vpsT gene; it could be the link between biofilm formation and QS.[1]
| VqmR sRNA | |
|---|---|
Predicted secondary structure and sequence conservation of VqmR small RNA | |
| Identifiers | |
| Rfam | RF02834 |
| Other data | |
| Domain | Bacteria |
| GO | GO:0042710 , GO:0040033 , GO:0003729 |
| SO | SO:0000370 |
| PDB structures | PDBe |
