WBP1

WW domain-binding protein 1 is a protein that in humans is encoded by the WBP1 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesWBP1, WBP-1, WW domain binding protein 1

External IDsOMIM: 606961; MGI: 104710; HomoloGene: 8267; GeneCards: WBP1; OMA:WBP1 - orthologs

Chr.Chromosome 2 (human)^[1]

Quick facts Available structures, PDB ...

WBP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1JMQ, 1K5R
Identifiers
Aliases	WBP1, WBP-1, WW domain binding protein 1
External IDs	OMIM: 606961; MGI: 104710; HomoloGene: 8267; GeneCards: WBP1; OMA:WBP1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.1 Start 74,458,400 bp[1] End 74,460,891 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 C3 Start 83,096,025 bp[2] End 83,098,540 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube pituitary gland amygdala nucleus accumbens anterior pituitary putamen caudate nucleus right adrenal cortex hippocampus proper left lobe of thyroid gland Top expressed in choroid plexus of fourth ventricle external carotid artery ventricular zone internal carotid artery vestibular sensory epithelium ganglionic eminence neural tube medial ganglionic eminence neural layer of retina maxillary prominence More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding WW domain binding Cellular component cellular component Biological process biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23559 22377 Ensembl ENSG00000239779 ENSMUSG00000030035 UniProt Q96G27 P97764 RefSeq (mRNA) NM_012477 NM_001083922 NM_001083923 NM_016757 RefSeq (protein) NP_036609 NP_001077391 NP_001077392 NP_058037 Location (UCSC) Chr 2: 74.46 – 74.46 Mb Chr 6: 83.1 – 83.1 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands.

This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by a conserved region: XPPXY motif. The function of this protein has not been determined.^[6]