WBP2

WW domain-binding protein 2 is a protein that in humans is encoded by the WBP2 gene.^[5][6]

AliasesWBP2, WBP-2, GRAMD6, WW domain binding protein 2, DFNB107

External IDsOMIM: 606962; MGI: 104709; HomoloGene: 32160; GeneCards: WBP2; OMA:WBP2 - orthologs

Chr.Chromosome 17 (human)^[1]

End75,856,507 bp^[1]

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WBP2
Identifiers
Aliases	WBP2, WBP-2, GRAMD6, WW domain binding protein 2, DFNB107
External IDs	OMIM: 606962; MGI: 104709; HomoloGene: 32160; GeneCards: WBP2; OMA:WBP2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 75,845,699 bp[1] End 75,856,507 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 115,969,399 bp[2] End 115,977,821 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe right hemisphere of cerebellum prefrontal cortex C1 segment right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex cingulate gyrus anterior cingulate cortex Top expressed in primary visual cortex neural layer of retina dentate gyrus of hippocampal formation granule cell superior frontal gyrus perirhinal cortex cerebellar cortex entorhinal cortex right kidney granulocyte CA3 field More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chromatin DNA binding protein binding RNA polymerase II core promoter sequence-specific DNA binding transcription coactivator activity estrogen receptor binding RNA polymerase II cis-regulatory region sequence-specific DNA binding Cellular component nucleus cytoplasm Biological process positive regulation of histone H3-K14 acetylation positive regulation of transcription by RNA polymerase II establishment of protein localization epigenetic maintenance of chromatin in transcription-competent conformation cellular response to estrogen stimulus response to progesterone positive regulation of intracellular estrogen receptor signaling pathway response to estrogen progesterone receptor signaling pathway transcription by RNA polymerase II positive regulation of nucleic acid-templated transcription Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23558 22378 Ensembl ENSG00000132471 ENSMUSG00000034341 UniProt Q969T9 P97765 RefSeq (mRNA) NM_012478 NM_001330499 NM_001348170 NM_016852 NM_001347642 NM_001361446 RefSeq (protein) NP_001317428 NP_036610 NP_001335099 NP_001334571 NP_058548 NP_001348375 Location (UCSC) Chr 17: 75.85 – 75.86 Mb Chr 11: 115.97 – 115.98 Mb PubMed search [3] [4]
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The globular WW domain is composed of 38 to 40 semiconserved amino acids shared by proteins of diverse functions including structural, regulatory, and signaling proteins. The domain is involved in mediating protein-protein interactions through the binding of polyproline ligands. This gene encodes a WW domain binding protein, which binds to the WW domain of Yes kinase-associated protein by its PY motifs. The function of this protein has not been determined.^[6]