WDR1

WD repeat-containing protein 1 is a protein that in humans is encoded by the WDR1 gene.^[5][6]

AliasesWDR1, AIP1, HEL-S-52, NORI-1, WD repeat domain 1, PFITS

External IDsOMIM: 604734; MGI: 1337100; HomoloGene: 6628; GeneCards: WDR1; OMA:WDR1 - orthologs

Chr.Chromosome 4 (human)^[1]

End10,116,949 bp^[1]

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WDR1
Identifiers
Aliases	WDR1, AIP1, HEL-S-52, NORI-1, WD repeat domain 1, PFITS
External IDs	OMIM: 604734; MGI: 1337100; HomoloGene: 6628; GeneCards: WDR1; OMA:WDR1 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4p16.1 Start 10,074,339 bp[1] End 10,116,949 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 B3|5 20.63 cM Start 38,684,156 bp[2] End 38,720,564 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery tibial arteries smooth muscle tissue right coronary artery body of uterus saphenous vein stromal cell of endometrium parotid gland thoracic aorta mucosa of sigmoid colon Top expressed in ankle joint granulocyte mesenteric lymph nodes stroma of bone marrow transitional epithelium of urinary bladder corneal stroma mucous cell of stomach tibiofemoral joint left colon molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding actin filament binding Cellular component extracellular region myelin sheath podosome cell junction cell projection extracellular exosome cytoskeleton actin filament cell-cell junction cytoplasm cytosol cortical actin cytoskeleton plasma membrane Biological process platelet degranulation hearing actin cytoskeleton organization regulation of ventricular cardiac muscle cell membrane repolarization regulation of oligodendrocyte differentiation maintenance of epithelial cell apical/basal polarity apical junction assembly regulation of actin filament depolymerization neutrophil mediated immunity regulation of cell shape actin filament fragmentation platelet formation positive regulation of actin filament depolymerization cortical cytoskeleton organization locomotion establishment of planar polarity of follicular epithelium sarcomere organization neutrophil migration actin filament depolymerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9948 22388 Ensembl ENSG00000071127 ENSMUSG00000005103 UniProt O75083 O88342 RefSeq (mRNA) NM_005112 NM_017491 NM_011715 RefSeq (protein) NP_005103 NP_059830 NP_035845 Location (UCSC) Chr 4: 10.07 – 10.12 Mb Chr 5: 38.68 – 38.72 Mb PubMed search [3] [4]
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This gene encodes a protein containing 9 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, mostly including a trp-asp at the C-terminal end. WD domains are involved in protein-protein interactions. The encoded protein may help induce the disassembly of actin filaments. Two transcript variants encoding different isoforms have been found for this gene.^[6]