WDR33

WD repeat-containing protein 33 is a protein that in humans is encoded by the WDR33 gene.^[5][6]

AliasesWDR33, NET14, WDC146, WD repeat domain 33

External IDsOMIM: 618082; MGI: 1921570; HomoloGene: 56807; GeneCards: WDR33; OMA:WDR33 - orthologs

Chr.Chromosome 2 (human)^[1]

End127,811,187 bp^[1]

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WDR33
Identifiers
Aliases	WDR33, NET14, WDC146, WD repeat domain 33
External IDs	OMIM: 618082; MGI: 1921570; HomoloGene: 56807; GeneCards: WDR33; OMA:WDR33 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.3 Start 127,701,027 bp[1] End 127,811,187 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 B1 Start 31,937,143 bp[2] End 32,040,450 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium vena cava amniotic fluid oocyte tibia Achilles tendon ganglionic eminence secondary oocyte endothelial cell cerebellar hemisphere Top expressed in otic vesicle saccule otic placode Rostral migratory stream zygote internal carotid artery vestibular membrane of cochlear duct fetal liver hematopoietic progenitor cell condyle secondary oocyte More reference expression data BioGPS n/a
Gene ontology Molecular function RNA binding Cellular component mRNA cleavage and polyadenylation specificity factor complex collagen nucleus fibrillar center nucleoplasm Biological process mRNA processing mRNA cleavage postreplication repair spermatogenesis mRNA splicing, via spliceosome termination of RNA polymerase II transcription mRNA export from nucleus mRNA 3'-end processing mRNA polyadenylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55339 74320 Ensembl ENSG00000136709 ENSMUSG00000024400 UniProt Q9C0J8 Q8K4P0 RefSeq (mRNA) NM_001006622 NM_001006623 NM_018383 NM_001170966 NM_001170967 NM_001170970 NM_028866 RefSeq (protein) NP_001006623 NP_001006624 NP_060853 NP_001164437 NP_001164438 NP_001164441 NP_083142 Location (UCSC) Chr 2: 127.7 – 127.81 Mb Chr 18: 31.94 – 32.04 Mb PubMed search [3] [4]
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This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.^[6]