WDR5

WD repeat-containing protein 5 is a protein that in humans is encoded by the WDR5 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesWDR5, BIG-3, CFAP89, SWD3, WD repeat-containing protein 5, WD repeat domain 5

External IDsOMIM: 609012; MGI: 2155884; HomoloGene: 59931; GeneCards: WDR5; OMA:WDR5 - orthologs

Chr.Chromosome 9 (human)^[1]

Quick facts Available structures, PDB ...

WDR5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CNX, 2CO0, 2G99, 2G9A, 2GNQ, 2H13, 2H14, 2H68, 2H6K, 2H6N, 2H6Q, 2H9L, 2H9M, 2H9N, 2H9P, 2O9K, 3EG6, 3EMH, 3MXX, 3N0D, 3N0E, 3P4F, 3PSL, 3SMR, 3UR4, 3UVK, 3UVL, 3UVM, 3UVN, 3UVO, 4A7J, 4CY1, 4CY2, 4ERQ, 4ERY, 4ERZ, 4ES0, 4ESG, 4EWR, 4GM3, 4GM8, 4GM9, 4GMB, 4IA9, 4O45, 4QL1, 4Y7R, 5EAL, 5EAP, 5EAR, 4QQE, 5EAM
Identifiers
Aliases	WDR5, BIG-3, CFAP89, SWD3, WD repeat-containing protein 5, WD repeat domain 5
External IDs	OMIM: 609012; MGI: 2155884; HomoloGene: 59931; GeneCards: WDR5; OMA:WDR5 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9q34.2 Start 134,135,365 bp[1] End 134,159,968 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 A3 Start 27,405,169 bp[2] End 27,426,547 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm left testis right testis sperm gastrocnemius muscle cerebellar hemisphere right hemisphere of cerebellum anterior pituitary secondary oocyte gonad Top expressed in secondary oocyte primary oocyte zygote primitive streak medullary collecting duct epiblast granulocyte renal corpuscle somite ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function histone methyltransferase activity (H3-K4 specific) histone acetyltransferase activity (H4-K8 specific) histone acetyltransferase activity (H4-K5 specific) methylated histone binding protein binding histone acetyltransferase activity (H4-K16 specific) histone-lysine N-methyltransferase activity histone binding Cellular component Set1C/COMPASS complex intracellular anatomical structure nucleoplasm MLL1 complex MLL3/4 complex histone acetyltransferase complex nucleus histone methyltransferase complex ciliary basal body Biological process skeletal system development regulation of transcription, DNA-templated transcription, DNA-templated histone H4-K5 acetylation histone H3-K4 methylation histone H3 acetylation histone H4-K16 acetylation neuron projection development histone H4-K8 acetylation cilium assembly post-translational protein modification regulation of megakaryocyte differentiation chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11091 140858 Ensembl ENSG00000196363 ENSMUSG00000026917 UniProt P61964 P61965 RefSeq (mRNA) NM_017588 NM_052821 NM_080848 RefSeq (protein) NP_060058 NP_438172 NP_543124 Location (UCSC) Chr 9: 134.14 – 134.16 Mb Chr 2: 27.41 – 27.43 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified.^[6]