WNT2

Wingless-type MMTV integration site family, member 2, also known as WNT2, is a human gene.^[5][6]

AliasesWNT2, INT1L1, IRP, Wnt family member 2

External IDsOMIM: 147870; MGI: 98954; HomoloGene: 20719; GeneCards: WNT2; OMA:WNT2 - orthologs

Chr.Chromosome 7 (human)^[1]

End117,323,152 bp^[1]

Quick facts Identifiers, Aliases ...

WNT2
Identifiers
Aliases	WNT2, INT1L1, IRP, Wnt family member 2
External IDs	OMIM: 147870; MGI: 98954; HomoloGene: 20719; GeneCards: WNT2; OMA:WNT2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q31.2 Start 117,275,451 bp[1] End 117,323,152 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 A2|6 8.08 cM Start 17,988,939 bp[2] End 18,030,584 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium placenta lower lobe of lung upper lobe of left lung testicle right lung gonad visceral pleura decidua amniotic fluid Top expressed in prostatic urethra septum transversum muscle layer of urethra lamina propria of prostatic urethra abdominal wall left lung lobe sinus venosus umbilical cord primordial ventricle lamina propria of vagina More reference expression data BioGPS n/a
Gene ontology Molecular function frizzled binding signaling receptor binding cytokine activity protein binding receptor ligand activity Cellular component cytoplasm extracellular matrix Wnt signalosome plasma membrane extracellular region extracellular space extrinsic component of external side of plasma membrane collagen-containing extracellular matrix Biological process positive regulation of mesenchymal cell proliferation positive regulation of cardiac muscle cell proliferation positive regulation of endothelial cell proliferation mammary gland epithelium development lung development cell-cell signaling multicellular organism development positive regulation of DNA-binding transcription factor activity neurogenesis lens development in camera-type eye cardiac epithelial to mesenchymal transition lung induction cellular response to retinoic acid iris morphogenesis cellular response to transforming growth factor beta stimulus positive regulation of epithelial cell proliferation involved in lung morphogenesis positive regulation of cell population proliferation positive regulation of transcription by RNA polymerase II cell fate commitment labyrinthine layer blood vessel development positive regulation of fibroblast proliferation atrial cardiac muscle tissue morphogenesis positive regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway neuron differentiation midbrain dopaminergic neuron differentiation canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation Wnt signaling pathway regulation of signaling receptor activity cell proliferation in midbrain Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7472 22413 Ensembl ENSG00000105989 ENSMUSG00000010797 UniProt P09544 P21552 RefSeq (mRNA) NM_003391 NM_023653 RefSeq (protein) NP_003382 NP_076142 Location (UCSC) Chr 7: 117.28 – 117.32 Mb Chr 6: 17.99 – 18.03 Mb PubMed search [3] [4]
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This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes that encode secreted signaling proteins involved in the Wnt signaling pathway. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene.^[5]