WNT5B

Protein Wnt-5b is a protein that in humans is encoded by the WNT5B gene.^[5][6]

AliasesWNT5B, Wnt family member 5B

External IDsOMIM: 606361; MGI: 98959; HomoloGene: 22530; GeneCards: WNT5B; OMA:WNT5B - orthologs

Chr.Chromosome 12 (human)^[1]

End1,647,212 bp^[1]

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WNT5B
Identifiers
Aliases	WNT5B, Wnt family member 5B
External IDs	OMIM: 606361; MGI: 98959; HomoloGene: 22530; GeneCards: WNT5B; OMA:WNT5B - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.33 Start 1,529,891 bp[1] End 1,647,212 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 F1|6 56.86 cM Start 119,409,492 bp[2] End 119,521,308 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium periodontal fiber prostate muscle layer of sigmoid colon minor salivary glands palpebral conjunctiva tibia ventricular zone olfactory zone of nasal mucosa testicle Top expressed in epithelium of lens renal corpuscle lamina propria of urethra primitive streak adventitia of seminal vesicle aortic valve adrenal medulla internal carotid artery vas deferens conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function frizzled binding signaling receptor binding Cellular component endocytic vesicle membrane endoplasmic reticulum lumen plasma membrane extracellular region cell surface Golgi lumen extracellular exosome extracellular space extracellular matrix collagen-containing extracellular matrix Biological process cellular response to retinoic acid cell fate commitment chondrocyte differentiation positive regulation of cell migration wound healing multicellular organism development neuron differentiation positive regulation of fat cell differentiation fat cell differentiation negative regulation of canonical Wnt signaling pathway lens fiber cell development Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 81029 22419 Ensembl ENSG00000111186 ENSMUSG00000030170 UniProt Q9H1J7 P22726 RefSeq (mRNA) NM_030775 NM_032642 NM_001271757 NM_001271758 NM_009525 RefSeq (protein) NP_110402 NP_116031 NP_001258686 NP_001258687 NP_033551 Location (UCSC) Chr 12: 1.53 – 1.65 Mb Chr 6: 119.41 – 119.52 Mb PubMed search [3] [4]
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The WNT gene family consists of structurally-related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 94% and 80% amino acid identity to the mouse Wnt5b protein and the human WNT5A protein, respectively. Alternative splicing of this gene generates two transcript variants.^[6]