WNT9A

Protein Wnt-9a (formerly Wnt14^[5]) is a protein that in humans is encoded by the WNT9A gene.^[6][7]

AliasesWNT9A, WNT14, Wnt family member 9A

External IDsOMIM: 602863; MGI: 2446084; HomoloGene: 20722; GeneCards: WNT9A; OMA:WNT9A - orthologs

Chr.Chromosome 1 (human)^[1]

End227,947,932 bp^[1]

Quick facts Identifiers, Aliases ...

WNT9A
Identifiers
Aliases	WNT9A, WNT14, Wnt family member 9A
External IDs	OMIM: 602863; MGI: 2446084; HomoloGene: 20722; GeneCards: WNT9A; OMA:WNT9A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.13 Start 227,918,656 bp[1] End 227,947,932 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 59,197,754 bp[2] End 59,224,378 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua oocyte gastrocnemius muscle muscle of thigh tendon of biceps brachii parotid gland muscle layer of sigmoid colon secondary oocyte tibialis anterior muscle mucosa of paranasal sinus Top expressed in urethra lumbar spinal ganglion ramus of the mandible lamina propria of urethra prostatic urethra muscle layer of urethra muscle layer of seminal vesicle muscular layer of prostatic urethra tibialis anterior muscle triceps brachii muscle More reference expression data BioGPS n/a
Gene ontology Molecular function frizzled binding signaling receptor binding receptor ligand activity Cellular component extracellular region extracellular space Biological process embryonic skeletal system morphogenesis cellular response to retinoic acid cell fate commitment negative regulation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of cartilage development embryonic skeletal joint development positive regulation of smoothened signaling pathway anatomical structure development mitotic cell cycle checkpoint signaling iris morphogenesis cornea development in camera-type eye cell-cell signaling negative regulation of cell death multicellular organism development negative regulation of chondrocyte differentiation positive regulation of cell differentiation neuron differentiation embryonic forelimb morphogenesis negative regulation of cell population proliferation Wnt signaling pathway regulation of signaling receptor activity canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7483 216795 Ensembl ENSG00000143816 ENSMUSG00000000126 UniProt O14904 Q8R5M2 RefSeq (mRNA) NM_003395 NM_139298 RefSeq (protein) NP_003386 NP_647459 Location (UCSC) Chr 1: 227.92 – 227.95 Mb Chr 11: 59.2 – 59.22 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It is expressed in gastric cancer cell lines. The protein encoded by this gene shows 75% amino acid identity to chicken Wnt14, which has been shown to play a central role in initiating synovial joint formation in the chick limb. This gene is clustered with another family member, WNT3A, in the chromosome 1q42 region.^[7]