Wikipedia talk:WikiProject Pharmacology

Hello, I am looking for pharamcodynamics (Ki numbers) for alimemazine from this database, but I can't figure out how to search drugs. Can anyone help me please? — Preceding unsigned comment added by Hplotter (talk • contribs) 16:44, 29 December 2025 (UTC)

Hi Hplotter. I saw your question just now and thought I'd respond. Unfortunately I don't believe it really has a search function. You go here and under "Test Ligand:" you select the compound you want from the dropdown box. Or you put the compound name in the text box, but if you do that, it has to match the name they have exactly. I suppose the text box is kind of search-esque, albeit very limited. They should really update their site. Unfortunately, I don't see alimemazine in their database. An alternative with a search feature is BindingDB. But it has different and often smaller datasets for compounds in my experience. And it has some stability issues and often doesn't want to load. I use both when making activity tables for drugs on Wiki personally. – AlyInWikiWonderland (talk, contribs) 19:58, 25 January 2026 (UTC)

Searching the alternate name Trimeprazine under 'Test Ligand' in the Ki database you've linked returns an experiment that records a K_i of 1.3 nM against the Histamine H1 receptor. Under the linked aliases for Trimeprazine it seems that you can also search for compounds using canonical SMILES strings. That combined with the wildcard symbols should hopefully make that field usable for searching, though still unfriendly. ⇌ Synpath 21:33, 25 January 2026 (UTC)

Amino acid has been nominated for a good article reassessment. If you are interested in the discussion, please participate by adding your comments to the reassessment page. If concerns are not addressed during the review period, the good article status may be removed from the article. Z1720 (talk) 15:56, 22 November 2025 (UTC)

For WikiProjects that participate in rating articles, the banners for talk pages usually say something like:

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There is a proposal to change the default wording on the banners to say "priority" instead of "importance". This could affect the template for your group. Please join the discussion at Wikipedia talk:WikiProject Council#Proposal to update wording on WikiProject banners. Stefen 𝕋ower ^{Huddle • Handiwerk} 19:47, 6 December 2025 (UTC) (on behalf of the WikiProject Council)

Hello! As part of my work for Beutler Ink, on behalf of Novo Nordisk, I've posted an edit request on the Novo Nordisk Talk page. I thought editors here might be interested in taking a look. Cheers, BINK Robin (talk) 18:36, 9 December 2025 (UTC)

Various of these substances, such as steareth 10, steareth 20, laureth 23, etc., are common components of pharmaceuticals and probably of cosmetics and foodstuffs, but are red-links at WP. They should be covered somewhere, at least in brief and with redirects to the sections.  — SMcCandlish ☏ ¢ 😼  20:17, 19 December 2025 (UTC)

Make a draft, then? WP:BOLD etc. Fishsicles (talk) 20:45, 19 December 2025 (UTC)

If there's a list of "chemical articles we should probably have", that is a good thing to present somewhere. Right now I am just slowly working through the list of recently-approved pesticides, but a topic with more background would be a change of pace. Just looking at laureth-23, these might be problematic to describe as discrete chemicals due to being more likely a mixture and not having a discrete structure (https://pubchem.ncbi.nlm.nih.gov/compound/Alcohols_-C12-16_-ethoxylated-_CAS-68551-12-2)? I had trouble with another compound I found from a list of ingredients on concrete etching solutions. I also find it hard to see what would distinguish steareth 10 (which would be two more carbons on Polyethylene glycol cetyl ether, as Polyethylene glycol octadecyl ether?) from any number of other very similar waxy solids. -- Reconrabbit 20:47, 19 December 2025 (UTC)

Steareth 10 would be a specific type of polyethylene glycol octadecyl ether (i.e. average of 10 PEG units attached to a stearyl alochol unit). Probably not worthy of its own article and arguably many of the chemicals in this ethoxylated alcohol class should be folded into a single article. Anonrfjwhuikdzz (talk) 01:35, 21 December 2025 (UTC)

I'd recommend redirecting to an appropriate page. As these ingredients are all non-ionic surfactants. My recommendation would be to create a page on non-ionic surfactants or the appropriate subset of ethoxylated alcohols and point the various cosmetic/foodstuff/pharma ingredients to the general page. It would be more informative to a general reader than having info about specific compounds as pages that don't give much beyond a WP:DICDEF like Isoceteth-20 are not as informative as a page about the general class of compounds.

There will be differences in performance among the specific ingredients, but discussing these exhaustively would likely go against WP:NOTJOURNAL and WP:NOTTEXTBOOK. Anonrfjwhuikdzz (talk) 01:19, 21 December 2025 (UTC)

Of existing articles, the best for these might be narrow-range ethoxylate which I would recommend renaming to alcohol ethoxylate. Info about these ingredients/nonionic surfactants can be added there and then redirects can be put in place. Anonrfjwhuikdzz (talk) 01:27, 21 December 2025 (UTC)

Welcome to the world of performance chemicals, where the specification is usually 'will it do X?' and the question of 'what exactly is it?' can't really be answered by the people who make it, use it, or regulate it. ECHA uses the term UVCB: Unknown or Variable composition, Complex reaction products, or Biological materials. Some alcohol exothoxylates will definitely fall into this description. As has been pointed out, the number of ethoxylate units is given as an average - but the exact distributions with in that can vary from supplier to supplier depending on what technology they use. Lauryl alcohol can mean anything from 'mostly C12, mostly linear, mostly saturated' to pure n-dodecanol. If the alcohol is coming from a plant source the composition can change depending on the plant, region and even time of year, such that even the output of a single producer can be variable. Producers can push their luck with what CAS number they register a product under, hoping to avoid GHS hazard symbols or certain tariff codes. Relatively small amounts of cleaner, high purity material might be produced specifically for pharmaceuticals, to meet exacting requirements - but will fall under the same name. All these versions will of course perform much the same as one another but it makes article writing difficult. You might be able to make tables; the various laureths, their CAS numbers and idealised structures. --Project Osprey (talk) 23:20, 19 December 2025 (UTC)

For those interested in contributing, I have done the bold thing and created a draft page on alcohol ethoxylates. Anonrfjwhuikdzz (talk) 05:17, 21 December 2025 (UTC)

Potassium has been nominated for a good article reassessment. If you are interested in the discussion, please participate by adding your comments to the reassessment page. If concerns are not addressed during the review period, the good article status may be removed from the article. Z1720 (talk) 03:25, 18 January 2026 (UTC)

Just notifying members of this project that there is a Conflict of Interest edit request relevant to this WikiProject at the Brenipatide article. DrThneed (talk) 04:04, 9 March 2026 (UTC)