Butyrate—CoA ligase
Type of enzyme
From Wikipedia, the free encyclopedia
Butyrate—CoA ligase, also known as xenobiotic/medium-chain fatty acid-ligase (XM-ligase), is an enzyme (EC 6.2.1.2) that catalyzes the chemical reaction:
- ATP + a carboxylic acid + CoA AMP + diphosphate + an acyl-CoA
| Butyrate—CoA ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 6.2.1.2 | ||||||||
| CAS no. | 9080-51-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The 3 substrates of this enzyme are ATP, carboxylic acid, and CoA, whereas its 3 products are AMP, diphosphate, and acyl-CoA.
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. This enzyme participates in the glycine conjugation of xenobiotics[1] and butanoate metabolism.
Nomenclature
The systematic name of this enzyme class is butanoate:CoA ligase (AMP-forming). Other names in common use include:
- butyryl-CoA synthetase, fatty acid thiokinase (medium chain),
- acyl-activating enzyme, fatty acid elongate,
- fatty acid activating enzyme,
- fatty acyl coenzyme A synthetase,
- medium chain acyl-CoA synthetase,
- butyryl-coenzyme A synthetase,
- L-(+)-3-hydroxybutyryl CoA ligase,
- xenobiotic/medium-chain fatty acid ligase, and
- short-chain acyl-CoA synthetase.
