XPOT

Exportin-T is a protein that in humans is encoded by the XPOT gene.^[5][6][7]

AliasesXPOT, XPO3, exportin for tRNA

External IDsOMIM: 603180; MGI: 1920442; HomoloGene: 38291; GeneCards: XPOT; OMA:XPOT - orthologs

Chr.Chromosome 12 (human)^[1]

End64,451,125 bp^[1]

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XPOT
Identifiers
Aliases	XPOT, XPO3, exportin for tRNA
External IDs	OMIM: 603180; MGI: 1920442; HomoloGene: 38291; GeneCards: XPOT; OMA:XPOT - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q14.2 Start 64,404,392 bp[1] End 64,451,125 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 D2 Start 121,423,285 bp[2] End 121,462,237 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium endothelial cell Brodmann area 23 islet of Langerhans Achilles tendon bone marrow cell ventricular zone body of pancreas middle temporal gyrus ganglionic eminence Top expressed in ureter lacrimal gland calvaria renal corpuscle fossa condyle parotid gland hair follicle substantia nigra medullary collecting duct More reference expression data BioGPS More reference expression data
Gene ontology Molecular function tRNA binding RNA binding Cellular component cytoplasm nuclear matrix nuclear pore nucleus nucleoplasm cytosol Biological process intracellular protein transport tRNA re-export from nucleus tRNA export from nucleus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11260 73192 Ensembl ENSG00000184575 ENSMUSG00000034667 UniProt O43592 Q9CRT8 RefSeq (mRNA) NM_007235 NM_001081056 NM_001359618 NM_001401044 NM_001401045 RefSeq (protein) NP_009166 NP_001074525 NP_001346547 NP_001387973 NP_001387974 Location (UCSC) Chr 12: 64.4 – 64.45 Mb Chr 10: 121.42 – 121.46 Mb PubMed search [3] [4]
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This gene encodes a protein belonging to the RAN-GTPase exportin family that mediates export of tRNA from the nucleus to the cytoplasm. Translocation of tRNA to the cytoplasm occurs once exportin has bound both tRNA and GTP-bound RAN.^[7]