ZHX3

Zinc fingers and homeoboxes protein 3 is a protein that in humans is encoded by the ZHX3 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesZHX3, TIX1, zinc fingers and homeoboxes 3

External IDsOMIM: 609598; MGI: 2444772; HomoloGene: 9000; GeneCards: ZHX3; OMA:ZHX3 - orthologs

Chr.Chromosome 20 (human)^[1]

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ZHX3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2DA5, 2DN0
Identifiers
Aliases	ZHX3, TIX1, zinc fingers and homeoboxes 3
External IDs	OMIM: 609598; MGI: 2444772; HomoloGene: 9000; GeneCards: ZHX3; OMA:ZHX3 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q12 Start 41,178,448 bp[1] End 41,317,672 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H2 Start 160,590,628 bp[2] End 160,714,918 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve gastric mucosa Achilles tendon ventricular zone corpus callosum stromal cell of endometrium popliteal artery tibial arteries internal globus pallidus nucleus accumbens Top expressed in otolith organ utricle zygote secondary oocyte spermatid vestibular membrane of cochlear duct lumbar subsegment of spinal cord seminiferous tubule ascending aorta aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding protein binding protein homodimerization activity transcription corepressor activity metal ion binding protein heterodimerization activity nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm Biological process cell differentiation positive regulation of osteoblast differentiation negative regulation of transcription, DNA-templated regulation of transcription, DNA-templated negative regulation of transcription by RNA polymerase II transcription, DNA-templated Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23051 320799 Ensembl ENSG00000174306 ENSMUSG00000035877 UniProt Q9H4I2 Q8C0Q2 RefSeq (mRNA) NM_015035 NM_177263 RefSeq (protein) NP_055850 NP_796237 Location (UCSC) Chr 20: 41.18 – 41.32 Mb Chr 2: 160.59 – 160.71 Mb PubMed search [3] [4]
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This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded Protein contains two C2H2-type zinc fingers and five Homeodomains and forms a Dimer with itself or with Zinc fingers and homeoboxes family member 1. In the Nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor.^[6]fx