ZRF1

DnaJ homolog subfamily C member 2 is a protein that in humans is encoded by the DNAJC2 gene.^[5][6]

PDBOrtholog search: PDBe RCSB

AliasesDNAJC2, MPHOSPH11, MPP11, ZRF1, ZUO1, DnaJ heat shock protein family (Hsp40) member C2

External IDsOMIM: 605502; MGI: 99470; HomoloGene: 31656; GeneCards: DNAJC2; OMA:DNAJC2 - orthologs

Chr.Chromosome 7 (human)^[1]

Quick facts DNAJC2, Available structures ...

DNAJC2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2M2E
Identifiers
Aliases	DNAJC2, MPHOSPH11, MPP11, ZRF1, ZUO1, DnaJ heat shock protein family (Hsp40) member C2
External IDs	OMIM: 605502; MGI: 99470; HomoloGene: 31656; GeneCards: DNAJC2; OMA:DNAJC2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q22.1 Start 103,312,289 bp[1] End 103,344,830 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5 A3|5 9.97 cM Start 21,962,265 bp[2] End 21,990,249 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve tendon of biceps brachii glutes nasal epithelium cartilage tissue hair follicle gonad Achilles tendon sperm monocyte Top expressed in tail of embryo genital tubercle seminiferous tubule epiblast spermatocyte spermatid primitive streak primary oocyte migratory enteric neural crest cell embryo More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding Hsp70 protein binding histone binding chromatin binding ATPase activator activity RNA binding ubiquitin modification-dependent histone binding protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm cytosol nuclear membrane nucleus nucleoplasm Biological process positive regulation of transcription, DNA-templated regulation of cellular response to heat DNA replication 'de novo' cotranslational protein folding regulation of transcription, DNA-templated negative regulation of DNA biosynthetic process transcription, DNA-templated positive regulation of ATP-dependent activity chromatin organization regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 27000 22791 Ensembl ENSG00000105821 ENSMUSG00000029014 UniProt Q99543 P54103 RefSeq (mRNA) NM_001129887 NM_014377 NM_001362667 NM_001362668 NM_009584 RefSeq (protein) NP_001123359 NP_055192 NP_001349596 NP_001349597 NP_033610 Location (UCSC) Chr 7: 103.31 – 103.34 Mb Chr 5: 21.96 – 21.99 Mb PubMed search [3] [4]
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This gene is a member of the M-phase phosphoprotein (MPP) family. The gene encodes a phosphoprotein with a J domain and a Myb DNA-binding domain which localizes to both the nucleus and the cytosol. The protein is capable of forming a heterodimeric complex that associates with ribosomes, acting as a molecular chaperone for nascent polypeptide chains as they exit the ribosome. This protein was identified as a leukemia-associated antigen and expression of the gene is upregulated in leukemic blasts. Also, chromosomal aberrations involving this gene are associated with primary head and neck squamous cell tumors. This gene has a pseudogene on chromosome 6. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.^[6]