Zavegepant

Zavegepant, sold under the brand name Zavzpret, is a medication used for the treatment of migraine.^[1] Zavegepant is a calcitonin gene-related peptide receptor antagonist.^[1] It is sprayed into the nose.^[1] It is sold by Pfizer.^[1]

Trade namesZavzpret

Other namesBHV-3500

License data

• US DailyMed: Zavegepant

Routes of
administrationNasal

Quick facts Clinical data, Trade names ...

Zavegepant

Clinical data
Trade names	Zavzpret
Other names	BHV-3500
License data	US DailyMed: Zavegepant
Routes of administration	Nasal
Drug class	Calcitonin gene-related peptide receptor antagonist
ATC code	N02CD08 (WHO)
Legal status
Legal status	US: ℞-only[1]
Identifiers
IUPAC name N-[(2R)-3-(7-methyl-1H-indazol-5-yl)-1-[4-(1-methylpiperidin-4-yl)piperazin-1-yl]-1-oxopropan-2-yl]-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide
CAS Number	1337918-83-8 as HCl: 1414976-20-7
PubChem CID	53472683 as HCl: 134819878
DrugBank	DB15688
ChemSpider	30814207
UNII	ODU3ZAZ94J as HCl: 000QCM6HAL
KEGG	D11898 as HCl: D11899
ChEBI	CHEBI:229643
ChEMBL	ChEMBL2397415 as HCl: ChEMBL4650220
CompTox Dashboard (EPA)	DTXSID101352039
Chemical and physical data
Formula	C36H46N8O3
Molar mass	638.817 g·mol−1
3D model (JSmol)	Interactive image
SMILES CC1=CC(=CC2=C1NN=C2)CC(C(=O)N3CCN(CC3)C4CCN(CC4)C)NC(=O)N5CCC(CC5)C6=CC7=CC=CC=C7NC6=O
InChI InChI=1S/C36H46N8O3/c1-24-19-25(20-28-23-37-40-33(24)28)21-32(35(46)43-17-15-42(16-18-43)29-9-11-41(2)12-10-29)39-36(47)44-13-7-26(8-14-44)30-22-27-5-3-4-6-31(27)38-34(30)45/h3-6,19-20,22-23,26,29,32H,7-18,21H2,1-2H3,(H,37,40)(H,38,45)(H,39,47)/t32-/m1/s1 Key:JJVAPHYEOZSKJZ-JGCGQSQUSA-N Key:VQDUWCSSPSOSNA-RYWNGCACSA-N

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The most common adverse reactions include taste disorders, nausea, nasal discomfort, and vomiting.^[1]

Zavegepant was approved for medical use in the United States in March 2023.^[1][2][3][4]