Zelandopam

Zelandopam (INNTooltip International Nonproprietary Name; developmental code names YM-435, MYD-37) is a selective dopamine D₁-like receptor agonist related to fenoldopam which was under development in Japan for the treatment of hypertension and heart failure but was never marketed.^[1][2][3] The drug was being developed for use by intravenous administration.^[1] The development of zelandopam appears to have been discontinued by the early 2000s.^[1] It was first described in the scientific literature by 1991.^[4]

Other namesSelandopam; (–)-(S)-7,8-Dihydroxy-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline; 7,8-DDPTI; YM-435; YM435; MYD-37; MYD37

Routes of
administrationIntravenous administration

Drug classDopamine D₁-like receptor agonists

CAS Number

• 139233-53-7
  138086-00-7 (hydrochloride)

Quick facts Clinical data, Other names ...

Zelandopam

Clinical data
Other names	Selandopam; (–)-(S)-7,8-Dihydroxy-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline; 7,8-DDPTI; YM-435; YM435; MYD-37; MYD37
Routes of administration	Intravenous administration
Drug class	Dopamine D1-like receptor agonists
Identifiers
IUPAC name (4S)-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline-7,8-diol
CAS Number	139233-53-7 138086-00-7 (hydrochloride)
PubChem CID	3078105
ChemSpider	2336394
UNII	IR6XYD8SAX
ChEMBL	ChEMBL2105532
CompTox Dashboard (EPA)	DTXSID2048820
Chemical and physical data
Formula	C15H15NO4
Molar mass	273.288 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1[C@H](C2=C(CN1)C(=C(C=C2)O)O)C3=CC(=C(C=C3)O)O
InChI InChI=1S/C15H15NO4/c17-12-3-1-8(5-14(12)19)10-6-16-7-11-9(10)2-4-13(18)15(11)20/h1-5,10,16-20H,6-7H2/t10-/m0/s1 Key:FULLEMQICAKPOE-JTQLQIEISA-N

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