Zipeprol

Zipeprol is a centrally acting cough suppressant developed in France in the 1970s.^[2] It is not a morphinan derivative (in contrast to both codeine and dextromethorphan). Zipeprol acts as a local anaesthetic and has mucolytic, antihistamine and anticholinergic properties.^[3] It is sold with several brand names such as Zinolta and Respilene. It is not available in the United States or Canada and has been discontinued in Europe. It is still available in some countries in Asia and South America.

AHFS/Drugs.comInternational Drug Names

Routes of
administrationOral

ATC code

• R05DB15 (WHO)

Legal status

• BR: Class F2 (Prohibited psychotropics)^[1]
• CA: Schedule III
• DE: Anlage II (Authorized trade only, not prescriptible)
• UK: Class B
• US: Schedule I
• UN: Psychotropic Schedule II

Quick facts Clinical data, AHFS/Drugs.com ...

Zipeprol

Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
ATC code	R05DB15 (WHO)
Legal status
Legal status	BR: Class F2 (Prohibited psychotropics)[1] CA: Schedule III DE: Anlage II (Authorized trade only, not prescriptible) UK: Class B US: Schedule I UN: Psychotropic Schedule II
Identifiers
IUPAC name 1-methoxy- 3-[4-(2-methoxy- 2-phenylethyl)piperazin- 1-yl]- 1-phenylpropan- 2-ol
CAS Number	34758-83-3 N
PubChem CID	36910
ChemSpider	33868 Y
UNII	G5MUV8139H
KEGG	D07390 Y
CompTox Dashboard (EPA)	DTXSID00865732
ECHA InfoCard	100.047.432
Chemical and physical data
Formula	C23H32N2O3
Molar mass	384.520 g·mol−1
3D model (JSmol)	Interactive image
SMILES OC(CN1CCN(CC1)CC(OC)c2ccccc2)C(OC)c3ccccc3
InChI InChI=1S/C23H32N2O3/c1-27-22(19-9-5-3-6-10-19)18-25-15-13-24(14-16-25)17-21(26)23(28-2)20-11-7-4-8-12-20/h3-12,21-23,26H,13-18H2,1-2H3 Y Key:VSTNNAYSCJQCQI-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

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Zipeprol has been misused in Korea as a deliriant. Such use is quite dangerous due to the risk of seizures and neurological damage at high dosages.^[4]