Α3IA

Chemical compound, anxiogenic From Wikipedia, the free encyclopedia

α3IA, also known as GTPL4094, is an inverse agonist of the GABAA receptor. It is more selective for the α3 subunit, hence its name.

Quick facts Names, Identifiers ...
α3IA[1]
Names
IUPAC name
Methyl 5-(4-methoxyphenyl)-1-methyl-2-oxo-6-pyridin-4-ylpyridine-3-carboxylate
Identifiers
3D model (JSmol)
ChEMBL
ChemSpider
  • InChI=1S/C20H18N2O4/c1-22-18(14-8-10-21-11-9-14)16(12-17(19(22)23)20(24)26-3)13-4-6-15(25-2)7-5-13/h4-12H,1-3H3
    Key: LENMNEQXCQXJHV-UHFFFAOYSA-N
  • CN1C(=C(C=C(C1=O)C(=O)OC)C2=CC=C(C=C2)OC)C3=CC=NC=C3
Properties
C20H18N2O4
Molar mass 350.374 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Effects

Agonism of the α3 subunit shows anxiolytic properties. However, by being an inverse agonist, α3IA has the opposite action: it shows anxiogenic properties.[2]

This compound also has affinity for the other subunits of the GABAA receptor, but it is more selective for the α3 subunit.[3]

See also

References

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