Caseína cinasa 2, alfa 1

La caseína cinasa 2 es una serina/treonina proteína cinasa que fosforila proteínas ácidas como la caseína. Esta proteína se dispone en forma de tetrámero y se compone de una subunidad alfa, una alfa prima y dos subunidades beta. La subunidad alfa contiene el sitio de actividad catalítica mientras que la subunidad beta se encarga de la autofosforilación. El gen CSNK2A1 codifica la subunidad alfa de este complejo y se localiza en el cromosoma 20, aunque se han descrito pseudogenes relacionados en el cromosoma 11. Se han encontrado tres variantes transcripcionales del gen que codifican dos isoformas diferentes de la proteína.^[3]

Interacciones

La caseína cinasa 2, alfa 1 ha demostrado ser capaz de interaccionar con:

CHEK1^[4]^[5]
FGF1^[6]
CDC25B^[7]
CREBBP^[8]
Factor de transcripción activador 2^[8]
c-Fos^[8]
MAPK14^[9]
RELA^[10]
PIN1^[11]
PLEKHO1^[12]
Caseína cinasa 2, beta^[13]^[14]^[12]^[15]^[16]
PTEN^[17]
ATF1^[8]
TAF1^[18]
UBTF^[19]
DDIT3^[20]
Factor de crecimiento de fibroblastos 2^[6]
APC^[21]
HNRPA2B1^[22]
c-Jun^[8]

Referencias

[1]
Lozeman FJ, Litchfield DW, Piening C, Takio K, Walsh KA, Krebs EG (Jan de 1991). «Isolation and characterization of human cDNA clones encoding the alpha and the alpha' subunits of casein kinase II». Biochemistry 29 (36): 8436-47. PMID 2174700.
[2]
Yang-Feng TL, Zheng K, Kopatz I, Naiman T, Canaani D (Feb de 1992). «Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit». Nucleic Acids Res 19 (25): 7125-9. PMC 332535. PMID 1766873.
[3]
«Entrez Gene: CSNK2A1 casein kinase 2, alpha 1 polypeptide».
[4]
Kristensen, Lars P; Larsen Martin R, Højrup Peter, Issinger Olaf-Georg, Guerra Barbara (Jul. de 2004). «Phosphorylation of the regulatory beta-subunit of protein kinase CK2 by checkpoint kinase Chk1: identification of the in vitro CK2beta phosphorylation site». FEBS Lett. (Netherlands) 569 (1-3): 217-23. ISSN 0014-5793. PMID 15225637. doi:10.1016/j.febslet.2004.05.069.
[5]
Guerra, Barbara; Issinger Olaf-Georg, Wang Jean Y J (Aug. de 2003). «Modulation of human checkpoint kinase Chk1 by the regulatory beta-subunit of protein kinase CK2». Oncogene (England) 22 (32): 4933-42. ISSN 0950-9232. PMID 12902976. doi:10.1038/sj.onc.1206721.
[6]
Skjerpen, Camilla Skiple; Nilsen Trine, Wesche Jørgen, Olsnes Sjur (Aug. de 2002). «Binding of FGF-1 variants to protein kinase CK2 correlates with mitogenicity». EMBO J. (England) 21 (15): 4058-69. ISSN 0261-4189. PMID 12145206.
[7]
Theis-Febvre, Nathalie; Filhol Odile, Froment Carine, Cazales Martine, Cochet Claude, Monsarrat Bernard, Ducommun Bernard, Baldin Véronique (Jan. de 2003). «Protein kinase CK2 regulates CDC25B phosphatase activity». Oncogene (England) 22 (2): 220-32. ISSN 0950-9232. PMID 12527891. doi:10.1038/sj.onc.1206107.
[8]
Yamaguchi, Y; Wada T; Suzuki F; Takagi T; Hasegawa J; Handa H (Aug. de 1998). «Casein kinase II interacts with the bZIP domains of several transcription factors». Nucleic Acids Res. (ENGLAND) 26 (16): 3854-61. ISSN 0305-1048. PMID 9685505.
[9]
Sayed, M; Kim S O, Salh B S, Issinger O G, Pelech S L (Jun. de 2000). «Stress-induced activation of protein kinase CK2 by direct interaction with p38 mitogen-activated protein kinase». J. Biol. Chem. (UNITED STATES) 275 (22): 16569-73. ISSN 0021-9258. PMID 10747897. doi:10.1074/jbc.M000312200.
[10]
Wang, D; Westerheide S D, Hanson J L, Baldwin A S (Oct. de 2000). «Tumor necrosis factor alpha-induced phosphorylation of RelA/p65 on Ser529 is controlled by casein kinase II». J. Biol. Chem. (UNITED STATES) 275 (42): 32592-7. ISSN 0021-9258. PMID 10938077. doi:10.1074/jbc.M001358200.
[11]
Messenger, Moira M; Saulnier Ronald B, Gilchrist Andrew D, Diamond Phaedra, Gorbsky Gary J, Litchfield David W (Jun. de 2002). «Interactions between protein kinase CK2 and Pin1. Evidence for phosphorylation-dependent interactions». J. Biol. Chem. (United States) 277 (25): 23054-64. ISSN 0021-9258. PMID 11940573. doi:10.1074/jbc.M200111200.
[12]
Bosc, D G; Graham K C, Saulnier R B, Zhang C, Prober D, Gietz R D, Litchfield D W (mayo. de 2000). «Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2». J. Biol. Chem. (UNITED STATES) 275 (19): 14295-306. ISSN 0021-9258. PMID 10799509.
[13]
Kim, M S; Lee Y T, Kim J M, Cha J Y, Bae Y S (Feb. de 1998). «Characterization of protein interaction among subunits of protein kinase CKII in vivo and in vitro». Mol. Cells (KOREA) 8 (1): 43-8. ISSN 1016-8478. PMID 9571630.
[14]
Marin, O; Meggio F, Sarno S, Pinna L A (Jun. de 1997). «Physical dissection of the structural elements responsible for regulatory properties and intersubunit interactions of protein kinase CK2 beta-subunit». Biochemistry (UNITED STATES) 36 (23): 7192-8. ISSN 0006-2960. PMID 9188720. doi:10.1021/bi962885q.
[15]
Ahn, B H; Kim T H, Bae Y S (Oct. de 2001). «Mapping of the interaction domain of the protein kinase CKII beta subunit with target proteins». Mol. Cells (Korea (South)) 12 (2): 158-63. ISSN 1016-8478. PMID 11710515.
[16]
Kusk, M; Ahmed R, Thomsen B, Bendixen C, Issinger O G, Boldyreff B (Jan. de 1999). «Interactions of protein kinase CK2beta subunit within the holoenzyme and with other proteins». Mol. Cell. Biochem. (NETHERLANDS) 191 (1-2): 51-8. ISSN 0300-8177. PMID 10094392.
[17]
Miller, Susan J; Lou David Y, Seldin David C, Lane William S, Neel Benjamin G (Sep. de 2002). «Direct identification of PTEN phosphorylation sites». FEBS Lett. (Netherlands) 528 (1-3): 145-53. ISSN 0014-5793. PMID 12297295.
[18]
Allende-Vega, Nerea; McKenzie Lynsey, Meek David (Sep. de 2008). «Transcription factor TAFII250 phosphorylates the acidic domain of Mdm2 through recruitment of protein kinase CK2». Mol. Cell. Biochem. (Netherlands) 316 (1-2): 99-106. ISSN 0300-8177. PMID 18548200. doi:10.1007/s11010-008-9816-3.
[19]
Voit, R; Kuhn A, Sander E E, Grummt I (Jul. de 1995). «Activation of mammalian ribosomal gene transcription requires phosphorylation of the nucleolar transcription factor UBF». Nucleic Acids Res. (ENGLAND) 23 (14): 2593-9. ISSN 0305-1048. PMID 7651819.
[20]
Ubeda, Mariano; Habener Joel F (Oct. de 2003). «CHOP transcription factor phosphorylation by casein kinase 2 inhibits transcriptional activation». J. Biol. Chem. (United States) 278 (42): 40514-20. ISSN 0021-9258. PMID 12876286. doi:10.1074/jbc.M306404200.
[21]
Homma, Miwako Kato; Li Dongxia, Krebs Edwin G, Yuasa Yasuhito, Homma Yoshimi (Apr. de 2002). «Association and regulation of casein kinase 2 activity by adenomatous polyposis coli protein». Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (9): 5959-64. ISSN 0027-8424. PMID 11972058. doi:10.1073/pnas.092143199.
[22]
Pancetti, F; Bosser R; Krehan A; Pyerin W; Itarte E; Bachs O (Jun. de 1999). «Heterogeneous nuclear ribonucleoprotein A2 interacts with protein kinase CK2». Biochem. Biophys. Res. Commun. (UNITED STATES) 260 (1): 17-22. ISSN 0006-291X. PMID 10381337. doi:10.1006/bbrc.1999.0849.

Datos: Q18248555

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